Browsing by Author "Qian, Xiaohong"

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    • ulk4 deficiency leads to hypomyelination in mice 

      Liu, Min; Xu, Ping; Guan, Zhenlong; Qian, Xiaohong; Dockery, Peter; Fitzgerald, Una; O'Brien, Timothy; Shen, Sanbing (Wiley-Blackwell, 2017-10-16)
      Brain nerve fibers are insulated by myelin which is produced by oligodendrocytes. Defects in myelination are increasingly recognized as a common pathology underlying neuropsychiatric and neurodevelopmental disorders, which ...

    • Ulk4 regulates GABAergic signaling and anxiety-related behavior 

      Liu, Min; Fitzgibbon, Marie; Wang, Yanqin; Reilly, Jamie; Qian, Xiaohong; O’Brien, Timothy; Clapcote, Steve; Shen, Sanbing; Roche, Michelle (Springer Nature, 2018-02-02)
      Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ...