Browsing by Author "O’Dwyer, Michael"

Now showing items 1-5 of 5

    • Drugging the unfolded protein response in acute leukemias 

      Kharabi Masouleh, Behzad; Chevet, Eric; Panse, Jens; Jost, Edgar; O’Dwyer, Michael; Bruemmendorf, Tim H.; Samali, Afshin (Springer Nature, 2015-07-16)
      The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1 alpha, PERK, and ATF6 alpha. Studies described the UPR as a critical ...

    • Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia 

      Burger, Jan A.; Tedeschi, Alessandra; Barr, Paul M.; Robak, Tadeusz; Owen, Carolyn; Ghia, Paolo; Bairey, Osnat; Hillmen, Peter; Bartlett, Nancy L.; Li, Jianyong; Simpson, David; Grosicki, Sebastian; Devereux, Stephen; McCarthy, Helen; Coutre, Steven; Quach, Hang; Gaidano, Gianluca; Maslyak, Zvenyslava; Stevens, Don A.; Janssens, Ann; Offner, Fritz; Mayer, Jiří; O’Dwyer, Michael; Hellmann, Andrzej; Schuh, Anna; Siddiqi, Tanya; Polliack, Aaron; Tam, Constantine S.; Suri, Deepali; Cheng, Mei; Clow, Fong; Styles, Lori; James, Danelle F.; Kipps, Thomas J. (New England Journal of Medicine (NEJM/MMS), 2015-12-17)
      BACKGROUND Chronic lymphocytic leukemia (CLL) primarily affects older persons who often have coexisting conditions in addition to disease-related immunosuppression and myelosuppression. We conducted an international, ...

    • Non-viral genome engineered CAR-NK cells for enhanced acute myeloid leukaemia targeting 

      Gurney, Mark (NUI Galway, 2023-11-27)
      Rapid developments in adoptive cell transfer (ACT) immunotherapy have led to the widespread use of chimeric antigen receptor (CAR)-T cell therapies in B-cell malignancies and multiple myeloma. Aiming to meet the need ...

    • Targeting aml through dr4 with a novel variant of rhtrail 

      Szegezdi, Eva; Reis, Carlos R.; Sloot, Almer M. van der; Natoni, Alessandro; O’Reilly, Aoife; Reeve, Janice; Cool, Robbert H.; O’Dwyer, Michael; Knapper, Steven; Serrano, Luis; Quax, Wim J.; Samali, Afshin (Wiley-Blackwell, 2011-09-26)
      Despite progress in the treatment of acute myelogenous leukaemia (AML) the outcome often remains poor. Tumour necrosis factor related apoptosis-inducing ligand (TRAIL) is a promising therapeutic agent in many different ...

    • The use of single armed observational data to closing the gap in otherwise disconnected evidence networks: a network meta-analysis in multiple myeloma 

      Schmitz, Susanne; Maguire, Áine; Morris, James; Ruggeri, Kai; Haller, Elisa; Kuhn, Isla; Leahy, Joy; Homer, Natalia; Khan, Ayesha; Bowden, Jack; Buchanan, Vanessa; O’Dwyer, Michael; Cook, Gordon; Walsh, Cathal (Springer Nature, 2018-06-28)
      Background: Network meta-analysis (NMA) allows for the estimation of comparative effectiveness of treatments that have not been studied in head-to-head trials; however, relative treatment effects for all interventions can ...