Browsing by Author "Hiom, Kevin"

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    • Brca1 is required for maintenance of phospho-chk1 and g2/m arrest during dna cross-link repair in dt40 cells 

      Draga, Margarethe; Madgett, Elizabeth B.; Vandenberg, Cassandra J.; du Plessis, David; Kaufmann, Aisling; Werler, Petra; Chakraborty, Prasun; Lowndes, Noel F.; Hiom, Kevin (American Society for Microbiology, 2015-08-31)
      The Fanconi anemia DNA repair pathway is pivotal for the efficient repair of DNA interstrand cross-links. Here, we show that FA-defective (Fancc(-)) DT40 cells arrest in G(2) phase following cross-link damage and trigger ...