Browsing by Author "Fulda, S"
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Histone deacetylase inhibitors cooperate with ifn-γ to restore caspase-8 expression and overcome trail resistance in cancers with silencing of caspase-8
Häcker, S; Dittrich, A; Mohr, A; Schweitzer, T; Rutkowski, S; Krauss, J; Debatin, K-M; Fulda, S (Springer Nature, 2009-07-13)Evasion of apoptosis can be caused by epigenetic silencing of caspase-8, a key component of the extrinsic apoptosis pathway. Loss of caspase-8 correlates with poor prognosis in medulloblastoma, which highlights the relevance ...