Browsing by Author "Calvo-Asensio, Irene"
Now showing items 1-4 of 4
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Atr activates the s-m checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset
Eykelenboom, John Kenneth; Harte, Emma Christina; Canavan, Lynn; Pastor-Peidro, Ana; Calvo-Asensio, Irene; Llorens-Agost, Marta; Lowndes, Noel Francis (Elsevier BV, 2013-11-01)Cells must accurately replicate and segregate their DNA once per cell cycle in order to successfully transmit genetic information. During S phase in the presence of agents that cause replication stress, ATR-dependent ... -
Differential response of mouse thymic epithelial cell types to ionizing radiation-induced dna damage
Calvo-Asensio, Irene; Barthlott, Thomas; von Muenchow, Lilly; Lowndes, Noel F.; Ceredig, Rhodri (Frontiers Media SA, 2017-04-13)Thymic epithelial cells (TECs) are the main components of the thymic stroma that support and control T-cell development. Preparative regimens using DNA-damaging agents, such as total body irradiation and/or chemotherapeutic ... -
Dn2 thymocytes activate a specific robust dna damage response to ionizing radiation-induced dna double-strand breaks
Calvo-Asensio, Irene; Sugrue, Tara; Bosco, Nabil; Rolink, Antonius; Ceredig, Rhodri (Frontiers Media SA, 2018-06-11)For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it ... -
The transcription factor hif-1 enhances the radio-resistance of mouse mscs
Calvo-Asensio, Irene; Dillon, Eugène T.; Lowndes, Noel F.; Ceredig, Rhodri (Frontiers Media SA, 2018-04-26)Mesenchymal stromal cells (MSCs) are multipotent progenitors supporting bone marrow hematopoiesis. MSCs have an efficient DNA damage response (DDR) and are consequently relatively radio-resistant cells. Therefore, MSCs are ...