Browsing by Author "Cabral, Joana"
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Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
Cabral, Joana; Hanley, Shirley A.; Gerlach, Jared Q.; O’Leary, Neil; Cunningham, Stephen; Ritter, Thomas; Ceredig, Rhodri; Joshi, Lokesh; Griffin, Matthew D. (Frontiers Media SA, 2017-08-21)Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ... -
Extracellular vesicles as modulators of wound healing
Cabral, Joana; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Elsevier, 2018-01-31)Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been ... -
Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers
Islam, Md Nahidul; Griffin, Tomás P.; Sander, Elizabeth; Rocks, Stephanie; Qazi, Junaid; Cabral, Joana; McCaul, Jasmin; McMorrow, Tara; Griffin, Matthew D. (BMC, 2019-11-19)Background: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. This study ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media SA, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ...