Browsing by Author "Bourke, Emer"

Now showing items 1-6 of 6

    • Centrosome amplification induced by dna damage occurs during a prolonged g2 phase and involves atm 

      Dodson, Helen; Bourke, Emer; Jeffers, Liam J; Vagnarelli, Paola; Sonoda, Eiichiro; Takeda, Shunichi; Earnshaw, William C; Merdes, Andreas; Morrison, Ciaran (Wiley-Blackwell, 2004-09-09)
      Centrosomes are the principal microtubule organising centres in somatic cells. Abnormal centrosome number is common in tumours and occurs after gamma-irradiation and in cells with mutations in DNA repair genes. To investigate ...

    • Clinically applicable inhibitors impacting genome stability 

      Prakash, Anu; Garcia-Moreno, Juan; Brown, James; Bourke, Emer (MDPI AG, 2018-05-13)
      Advances in technology have facilitated the molecular profiling (genomic and transcriptomic) of tumours, and has led to improved stratification of patients and the individualisation of treatment regimes. To fully realize ...

    • Hematopoietic stem cell quiescence promotes error-prone dna repair and mutagenesis 

      Mohrin, Mary; Bourke, Emer; Alexander, David; Warr, Matthew R.; Barry-Holson, Keegan; Le Beau, Michelle M.; Morrison, Ciaran G.; Passegué, Emmanuelle (Elsevier BV, 2010-08-01)
      Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes ...

    • Investigating the role of amplified centrosomes in tumourigenesis of breast cancer 

      Prakash, Anu (NUI Galway, 2021-06-28)
      Centrosomes, the major microtubule organising centre (MTOC) of cell play essential roles in regulating cell cycle control, spindle assembly and genomic stability. Centrosome amplification (CA), a numerical centrosomal ...

    • Rational design and validation of a tip60 histone acetyltransferase inhibitor 

      Gao, Chunxia; Bourke, Emer; Scobie, Martin; Famme, Melina Arcos; Koolmeister, Tobias; Helleday, Thomas; Eriksson, Leif A.; Lowndes, Noel F.; Brown, James A. L. (Springer Nature, 2014-06-20)
      Histone acetylation is required for many aspects of gene regulation, genome maintenance and metabolism and dysfunctional acetylation is implicated in numerous diseases, including cancer. Acetylation is regulated by histone ...

    • Rock activity and the gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells 

      Ryan, Caroline M.; Brown, James A. L.; Bourke, Emer; Prendergast, Áine M.; Kavanagh, Claire; Liu, Zhonglin; Owens, Peter; Shaw, Georgina; Kolch, Walter; O’Brien, Timothy; Barry, Frank P. (Springer Nature, 2015-07-24)
      Introduction: Bone marrow-derived stromal cells (BMSCs), also known as mesenchymal stem cells, are the focus of intensive efforts worldwide to elucidate their function and biology. Despite the importance of BMSC migration ...