Browsing by Author "Beatty, Rachel"
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Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform
Whyte, William; Goswami, Debkalpa; Wang, Sophie X.; Fan, Yiling; Ward, Niamh A.; Levey, Ruth E.; Beatty, Rachel; Robinson, Scott T.; Sheppard, Declan; O’Connor, Raymond; Monahan, David S.; Trask, Lesley; Mendez, Keegan L.; Varela, Claudia E.; Horvath, Markus A.; Wylie, Robert; O’Dwyer, Joanne; Domingo-Lopez, Daniel A.; Rothman, Arielle S.; Duffy, Garry P.; Dolan, Eimear B.; Roche, Ellen T. (Nature Research, 2022-08-03)Fibrous capsule (FC) formation, secondary to the foreign body response (FBR), impedes molecular transport and is detrimental to the long-term efficacy of implantable drug delivery devices, especially when tunable, temporal ... -
FibroSensing Dynamic Soft Reservoir (FSDSR): A bio-sensing drug delivery device for monitoring the foreign body response in real time
Beatty, Rachel (NUI Galway, 2022-12-19)Despite significant advancements in Type 1 diabetes mellitus (Type 1 DM) treatments, the foreign body response continues to prevent the longevity of implantable medical devices that treat the condition. The development ...