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Now showing items 746-765 of 14646
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Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley-Blackwell, 2013-08-01)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Altered nociceptive responding in animal models of affective disorders: role of monoamines and immune mediators
(2013-12-18)Depression and chronic pain share an intricate, complex relationship, the comorbidity of which is reported to affect up to 80% of patients. This thesis demonstrated enhanced nociceptive responding to mechanical and cold, ... -
Altered thermoregulatory responses to clonidine in streptozotocin-diabetic rats
(Wiley-Blackwell, 1996-03-01)1 The effects of streptozotocin (STZ) treatment on alpha(2)-adrenoceptor regulation of body temperature were studied by monitoring the response of colonic temperature to administration of clonidine. 2 A dose-dependent fall ... -
Altering legacies as ‘A Farmer in My Own Right’: married women's experiences of farm property ownership in Ireland
(NUI Galway, 2018-01-31)A number of women living on family farms own farm property in their own right. This is an unexplored research area in Ireland. Gender inequalities in the ownership and control of farm property have consequences for women’s ... -
Altering the granularity of neutrality in a multi-layered genetic algorithm
(SciTePress Digital Library, 2014)By adopting a basic interpretation of the biological processes of transcription and translation, the multilayered GA (MGA) introduces a genotype-phenotype mapping for a haploid genotype, which allows the granularity of the ... -
Alternate two-dimensional quantum walk with a single-qubit coin
(American Physical Society (APS), 2011-10-25)We have recently proposed a two-dimensional quantum walk where the requirement of a higher dimensionality of the coin space is substituted with the alternance of the directions in which the walker can move [C. Di Franco, ... -
Alternating bimetallic Na/Mn covalent and ionic chains
(RSC, 2010-07-30)The first coordination polymers constructed using the 2,2'-biphenol ligand are described along with their ionic supramolecular counterparts. -
Alternative energy imaginaries: Implications for energy research, policy integration and the transformation of energy systems
(Elsevier, 2021-01-16)The paper highlights shortcomings in the contribution of qualitative social sciences and humanities (SSH) research to tackling challenges connected with energy and climate change. These shortcomings are illustrated based ... -
An alternative gathering: public space and shared agency in the lived experience of multicultural Ireland
(2014-01-31)The overarching aim of this thesis is to understand the palette of complex ways in which a diverse community in Ireland responds to its challenges. This research, therefore, offers important insights into novel approaches ... -
Alternative uses for co-products: harnessing the potential of valuable compounds from meat processing chains
(Elsevier BV, 2017-10-01)Opportunities for exploiting the inherent value of protein-rich meat processing co-products, in the context of increased global demand for protein and for sustainable processing systems, are discussed. While direct consumption ... -
Am I being watched? The role of researcher presence on toddlers’ behaviour during ‘everyday’ pain experiences: a pilot study
(Taylor & Francis, 2019-12-31)Objective: Paediatric research on 'everyday' pain experiences is sparse, stemming from a lack of appropriate methodologies. We explored the feasibility of two methodologies for conducting naturalistic observations of ... -
Ambra1 links autophagy to cell proliferation and tumorigenesis by promoting c-myc dephosphorylation and degradation
(Springer Nature, 2014-12-01)Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent ... -
American and Irish perspectives on collaborative practice
(Thomson Reuters Round Hall, 2011)In their Report on Alternative Dispute Resolution,1 the Law Reform Commission (LRC) have recognised Collaborative Practice as “an emerging method of advisory dispute resolution”,2 where, “the negotiation becomes client ... -
The American Indian movement and the Black Panther party compared: violence, the state and social movements in the USA, 1966 to 1976
(NUI Galway, 2020-04-30)The concepts of liberal democracy and pluralism evoke themes relating to justice, parity of esteem and the right of equal protection under the law. At the centre of these tenets is a state that is deemed to be both the ... -
Amine functionalization of cholecyst-derived extracellular matrix with generation 1 pamam dendrimer
(American Chemical Society (ACS), 2008-02-01)A method to functionalize cholecyst-derived extracellular matrix (CEM) with free amine groups was established in an attempt to improve its potential for tethering of bioactive molecules. CEM was incorporated with Generation-1 ... -
Aminotripeptidase activity in lactococcus lactis subsp cremoris am2
(Portland Press Ltd., 1991-02-01) -
Amorphous pharmaceuticals and composites
(NUI Galway, 2018-04-27)An attractive, yet challenging approach to overcome poor water solubility is to convert a crystalline Active Pharmaceutical Ingredient (API) into its more soluble amorphous form.1-3 Nevertheless, the use of amorphous drug ... -
Amorphous solid dispersions of sulfonamide/soluplus® and sulfonamide/pvp prepared by ball milling
(American Association of Pharmaceutical Scientists (AAPS), 2013-02-07)The aim of this paper is to investigate the physicochemical properties of binary amorphous dispersions of poorly soluble sulfonamide/polymeric excipient prepared by ball milling. The sulfonamides selected were sulfathiazole ... -
<i>phip</i> - a novel candidate breast cancer susceptibility locus on 6q14.1
(Impact Journals, LLC, 2017-11-28)Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent ...