Browsing by Author "Samali, Afshin"
Now showing items 41-60 of 65
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miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts
Samali, Afshin (2014)Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ... -
Mirna signature of unfolded protein response in h9c2 rat cardiomyoblasts
Read, Danielle E; Gupta, Ananya; Ladilov, Yury; Samali, Afshin; Gupta, Sanjeev (Springer Nature, 2014-01-01)Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ... -
The molecular characterization of ER stress-induced autophagy and cell death
Deegan, Shane (2012-12-21)Autophagy is tightly regulated by the unfolded protein response (UPR). It plays an important role in the removal of unfolded proteins, damaged mitochondria and expanded endoplasmic reticulum (ER), to help relieve ER stress ... -
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
Carleton, Laura A.; Doyle, Karen M.; Samali, Afshin; Gorman, Adrienne; Mnich, Katarzyna; Kavanagh, Edel T. (Nature Publishing Group, 2014-05-01)Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ... -
NGF-induced pro-survivla signalling: Molecular engineering of NGFto enhance pro-survival signalling
Carleton, Laura (2014-01-27)Nerve growth factor (NGF) is a potent pro-survival growth factor that has diverse roles in development and in the adult nervous system. It has two cognate receptors that stimulate distinct signalling pathways, tropomyosin-related ... -
Novel roles of the unfolded protein response in the control of tumor development and aggressiveness
Dejeans, Nicolas; Barroso, Kim; Fernandez-Zapico, Martin E.; Samali, Afshin; Chevet, Eric (Elsevier BV, 2015-08-01) -
Noxa contributes to the sensitivity of perk-deficient cells to er stress
Gupta, Sanjeev; Giricz, Zoltan; Natoni, Alessandro; Donnelly, Neysan; Deegan, Shane; Szegezdi, Eva; Samali, Afshin (Wiley-Blackwell, 2012-10-12) -
Perk regulated mir-424(322)-503 cluster fine-tunes activation of ire1 and atf6 during unfolded protein response
Gupta, Ananya; Hossain, Muhammad Mosaraf; Read, Danielle E.; Hetz, Claudio; Samali, Afshin; Gupta, Sanjeev (Springer Nature, 2015-12-17)The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ... -
The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis
van Dijk, Marianne; Murphy, Eoin; Morrell, Ruth; O'Dwyer, Michael; Szegezdi, Eva; Samali, Afshin (2011)Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents ... -
Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants
Natoni, Alessandro; Szegezdi, Eva; Samali, Afshin (Macmillan Publishers Limited, 2010)The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ... -
Regulation of apoptosis by heat shock proteins
Kennedy, Donna; Jäger, Richard; Mosser, Dick D; Samali, Afshin (Wiley-Blackwell, 2014-05-01) -
The regulation of ER stress induced cell death by HSPB1 (hsp27)
Kennedy, Donna (2013-01-29)Endoplasmic reticulum (ER) stress is associated with several human pathologies including neurodegenerative disorders. ER stress results in accumulation of unfolded proteins which activates the unfolded protein response ... -
Regulation of the unfolded protein response by noncoding rna
McMahon, Mari; Samali, Afshin; Chevet, Eric (American Physiological Society, 2017-09-01)Cells are exposed to various intrinsic and extrinsic stresses in both physiological and pathological conditions. To adapt to those conditions, cells have evolved various mechanisms to cope with the disturbances in protein ... -
Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways
Samali, Afshin (2013)Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine and a selective inducer of apoptosis in a range of tumour cells, but not in normal, untransformed cells. A large number of chemotherapeutics ... -
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells
Jaafar, Rola; Mnich, Katarzyna; Dolan, Sarah; Hillis, Jennifer; Almanza, Aitor; Logue, Susan E.; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2018-02-06)Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ... -
The role of IRE1α in the regulation of cytokine production
Talty, Aaron (NUI Galway, 2020-04-16)Inositol-requiring enzyme 1 (IRE1), a key mediator of the unfolded protein response (UPR), has emerging roles within innate immunity and cancer progression. Here we examine how IRE1 signalling influences the production ... -
The role of microRNAs during endoplasmic reticulum stress induced cell death
Cawley, Karen (2012-04-25)Endoplasmic Reticulum (ER) stress occurs in response to negative insult or stimuli to the cell. It induces a pathway called the unfolded protein response (UPR) which can alleviate stress and restore the cell to its ¿healthy ... -
Stem cells are resistant to trail receptor-mediated apoptosis
Szegezdi, Eva; O’Reilly, Aoife; Davy, Yeung; Vawda, Reaz; Taylor, Deanna L.; Murphy, Mary; Samali, Afshin; Mehmet, Huseyin (Wiley-Blackwell, 2009-11-01)New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ... -
Stress management at the ER: regulators of ER stress-induced apoptosis.
Gorman, Adrienne M.; Healy, Sandra J.M.; Jäger, Richard; Samali, Afshin (Elsevier, 2012-02-17)The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are ... -
Synthetic constrained peptide selectively binds and antagonizes death receptor 5
Vrielink, Johanna; Heins, Mariette S.; Setroikromo, Rita; Szegezdi, Eva; Mullally, Margaret M.; Samali, Afshin; Quax, Wim J. (Wiley-Blackwell, 2010-02-12)Apoptosis or programmed cell death is an inherent part of the development and homeostasis of multicellular organisms. Dysregulation of apoptosis is implicated in the pathogenesis of diseases such as cancer, neurodegenerative ...