Browsing by Subject "Breast cancer"
Now showing items 21-39 of 39
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Isolation of secreted microRNAs (miRNAs) from cell-conditioned media
(2013)MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ... -
The lysine acetyltransferase MOF: its interactome, role in breast cancer, and characterisation of a novel isoform
(2017-11-24)Males absent on the first (MOF), also known as hMOF, MYST1, or KAT8, is a lysine acetyltransferase responsible for bulk acetylation of Histone H4 at lysine 16 (H4K16ac), though it has also been shown to acetylate several ... -
Mastectomy and breast reconstruction in the modern era: the role of neoadjuvant therapies and regenerative surgery
(NUI Galway, 2018-10-09)Complete surgical resection with disease free margins remains the cornerstone of effective breast cancer treatment. Breast cancer management continues to evolve with the development of more sophisticated techniques of ... -
Meseanchymal stem cell mediated sodium iodide symporter gene therapy of breast cancer
(2014-05-07)Introduction: The Sodium Iodide Symporter (NIS) facilitates iodide accumulation in the thyroid and radioiodide imaging and treatment of thyroid disease. Studies have suggested that elevated levels of NIS expression in ... -
microRNA-mediated intercellular communication in the primary breast tumour microenvironment
(2014-08-30)microRNAs (miRNA) have been highlighted as potential circulating biomarkers and as therapeutic targets for breast cancer. Recent evidence suggests that miRNAs are transported in protective microvesicles called exosomes, ... -
MiRNAs as oncologic biomarkers for breast cancer
(2014-08-18)Understanding of the molecular complexity underlying breast cancer has greatly advanced in recent years. Distinct phenotypic subtypes have been identified each of which carry prognostic and predictive implications. Despite ... -
Molecular mechanisms and tumour heterogeneity in breast cancer
(2014-05-07)MicroRNAs play a critical role in regulation of gene expression and are known to be dysregulated in breast cancer. The aim of this study was investigate four microRNAs miR-875-5p, miR-339-5p, miR-10a and miR-379 which were ... -
Multi-omics analysis reveals novel roles for IRE1α in triple negative breast cancer (TNBC)
(NUI Galway, 2021-09-07)Constitutive aberrant IRE1α signalling has been previously reported in triple negative breast cancer (TNBC), where is suggested to contribute to the disease progression and therapy resistance. Despite its clinical relevance, ... -
Nerve Growth Factor in Cancer Cell Death and Survival
(MDPI, 2011-02)One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ... -
Neurotrophic signalling and inhibition in breast cancer and chronic lymphocytic leukaemia
(2016-01-15)Neurotrophins are important growth factors for neuronal cells. They interact with the Trk kinase receptors and the p75NTR receptor to induce several signaling pathways. Neurotrophins and their receptors are known regulators ... -
Novel mechanisms for neoadjuvant chemotherapeutic response monitoring in breast cancer
(2016-11-25)Breast cancer is the most frequently diagnosed female malignancy worldwide, causing the majority of cancer-related deaths amongst women. While the management of this disease has transformed dramatically in recent years, ... -
Performance of leading artifact removal algorithms assessed across microwave breast imaging prototype scan configurations
(Elsevier, 2017-03-02)Microwave imaging is a promising imaging modality for the detection of early-stage breast cancer. One of the most important signal processing components of microwave radar-based breast imaging is early stage artifact ... -
Photoacoustic imaging with clinical, preclinical, and quantitative applications
(NUI Galway, 2020-11-20)Photoacoustic (PA) imaging (PAI) is an emerging biomedical imaging modality that combines optical absorption contrast with ultrasonic resolution and imaging depth. Major research has been carried out into PAI in recent ... -
Pro-survival pathways in triple negative breast cancer: Focus on the roles of RIP2 and HSPB1
(2016-10-10)Triple negative breast cancers (TNBC) lack estrogen and progesterone receptors, and HER-2 markers rendering them resistant to current targeted therapies. Most TNBCs show basal-like characteristics and the terms TNBC and ... -
The prognostic value of protein and microRNA biomarkers in breast cancer and their role in tumour progression
(2014-05-14)Identification of biomarkers has proven valuable in prognostication and treatment stratification of individual cases of breast cancer. microRNAs, short non-coding RNA molecules which negatively regulate translation of mRNA, ... -
Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
(Elsevier, 2011-06-12)Purpose Investigate circulating CCL5 in breast cancer patients and healthy controls, along with gene expression levels in corresponding tumour tissue and isolated primary stromal cells. Hormonal control of CCL5, and a ... -
Role of MicroRNAs and unfolded protein response in breast cancer
(2017-11-24)Stressful conditions of the tumour microenvironment which overwhelm the folding capacity of the endoplasmic reticulum (EnR) activate an evolutionary conserved signalling pathway known as the unfolded protein response (UPR). ... -
Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
(Springer, 2008-06-04)Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic ... -
Vitamin D supplementation and clinical outcomes in cancer survivorship
(Mark Allen Healthcare, 2018-10-22)Increasing evidence points to the role of vitamin D supplementation in cancer management. A comprehensive search of online databases was undertaken for all research studies relating to vitamin D supplementation in cancer ...