Browsing by Title
Now showing items 3691-3710 of 14646
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Disrupting the status quo? Discrimination in academic promotions
(Thomson Round Hall, 2017)In June 2016 the HEA Report of the Expert Group: HEA National Review of Gender Equality in Higher Education Institutions (Gender Equality Review) reported and stated that there was a need for “radical action” without ... -
Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion
(2013)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Disruption of microrna biogenesis confers resistance to er stress-induced cell death upstream of the mitochondrion
(Public Library of Science (PLoS), 2013-08-19)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Disruption of NEDD8 protein conjugation as a novel therapy for acute myeloid leukemia
(2012-08-15)The coordinated balance between the synthesis and degradation of proteins is an important regulator of cancer cell biology. The ubiquitin-proteasome system (UPS) is responsible for the timed destruction of many proteins ... -
Disruption of the microtubule network alters cellulose deposition and causes major changes in pectin distribution in the cell wall of the green alga,penium margaritaceum
(Oxford University Press (OUP), 2013-11-27)Application of the dintroaniline compound, oryzalin, which inhibits microtubule formation, to the unicellular green alga Penium margaritaceum caused major perturbations to its cell morphology, such as swelling at the wall ... -
Dissecting optional micro-decisions in online transactions: perceptions, deceptions and errors
(Association for Computing Machinery (ACM), 2022-05-02)Online firms frequently increase profit by selling optional extras. However, opt-in rates tend to be low. In response, questionable design practices have emerged to nudge consumers into inadvertent choices. Many of these ... -
Dissecting the evolution of resistance to microtubule hyper-stabilization
(NUI Galway, 2024-01-31)When microtubules are hyper-stabilized, they do not provide the proper tension at the kinetochore of the metaphase chromosomes. Low tension leads to the activation of the spindle assembly checkpoint which stops cells ... -
Dissecting the monster: mapping discourses of medicine, ethics, and monstrosity in the Victorian Penny Blood
(2017-02-02)This research analyses a set of specimens of penny blood literature from the point of view of medical history, with the goal of providing an examination of the genre in relation to its historical context. In so doing, it ... -
Dissecting the pan-placodal gene regulatory network reveals novel interactions driving sense organ development in vertebrates
(2016-02-17)The genes encoding the transcription factor Six1, and its co-factor Eya1 together mark the embryonic territory - the pan-placodal ectoderm (PPE) - that gives rise to most cranial sense organs in vertebrates. Mutation of ... -
Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of six1 and eya1 in cranial placodes
(eLife Sciences Organisation, Ltd., 2016-08-31)The pre-placodal ectoderm, marked by the expression of the transcription factor Six1 and its co-activator Eya1, develops into placodes and ultimately into many cranial sensory organs and ganglia. Using RNA-Seq in Xenopus ... -
Dissecting the subcellular compartmentation of proteins and metabolites in arabidopsis leaves using non-aqueous fractionation
(American Society for Biochemistry & Molecular Biology (ASBMB), 2014-05-27)Non-aqueous fractionation is a technique for the enrichment of different subcellular compartments derived from lyophilized material. It was developed to study the subcellular distribution of metabolites. Here we analyzed ... -
Dissolution of delta phase in Ni-based superalloy during linear friction welding: integrated multiphysics computational process modelling
(Springer, 2021-06-15)Linear friction welding (LFW) is an increasingly popular solid-state joining method for challenging applications such as integrated blade disk of aero-engines. However, the influence of friction-generated heat on the ... -
Dissolved azaspiracids are absorbed and metabolized by blue mussels (mytilus edulis)
(Elsevier BV, 2013-04-01) -
Distance interaction between marine cave-dwelling sponges and crustaceans
(Springer Nature, 2018-07-01)Sponges are benthic organisms that are dominant in several ecosystems and known to produce a huge chemical diversity. The putative release of some specialized metabolites in the surrounding seawater is still a matter of ... -
Distance measured
(Springer Nature, 1980-08-01) -
Distancing to self-protect: The perpetuation of inequality in higher education through socio-relational dis/engagement
(2011)This paper explores the social class-differentiated behaviours of access and traditional-entry students, based on a three-year constructivist grounded theory study with 45 undergraduates at an Irish university. The participant ... -
Distinct brct domains in mcph1/brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
(Springer Nature, 2007-06-25)Microcephalin (MCPH1/BRIT1) forms ionizing radiation-induced nuclear foci (IRIF) and is required for DNA damage-responsive S and G(2)-M-phase checkpoints. MCPH1 contains three BRCT domains. Here we report the cloning of ... -
Distinct mechanisms underlie oral versus aboral regeneration in the cnidarian hydractinia echinata
(2014-10-24)Distinct mechanisms underlie oral versus aboral regeneration in Hydractinia echinata. Head regeneration is preceded by stem cell migration, proliferation and blastema formation. After decapitation stem cells migrate from ... -
Distinct mechanisms underlie oral vs aboral regeneration in the cnidarianhydractinia echinata
(eLife Sciences Organisation, Ltd., 2015-04-17)Cnidarians possess remarkable powers of regeneration, but the cellular and molecular mechanisms underlying this capability are unclear. Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation ... -
Distinctive activities of dna polymerases during human dna replication
(Wiley-Blackwell, 2006-07-01)The contributions of human DNA polymerases (pols) alpha, delta and epsilon during S-phase progression were studied in order to elaborate how these enzymes co-ordinate their functions during nuclear DNA replication. Pol ...