Search
Now showing items 1-7 of 7
Rapid lc-ms drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format
(American Chemical Society (ACS), 2009-12-15)
Silica nanoparticle bioreactors featuring thin films of enzymes and polyions were utilized in a novel high-throughput 96-well plate format for drug metabolism profiling. The utility of the approach was illustrated by ...
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
(Royal Society of Chemistry (RSC), 2009-01-01)
The conjugation of carbohydrates to synthetic scaffolds has the goal of preparing potent inhibitors of lectin binding. We herein report the synthesis of a panel of bivalent compounds (cyclophane and terephthalamide-derivatives) ...
Restriction of human polyomavirus bk virus dna replication in murine cells and extracts
(American Society for Microbiology, 2009-03-18)
BK virus (BKV) causes persistent and asymptomatic infections in most humans and is the etiologic agent of polyomavirus-associated nephropathy (PVAN) and other pathologies. Unfortunately, there are no animal models with ...
The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia
(American Association for Cancer Research (AACR), 2009-10-13)
Pyrrolo-1,5-benzoxazepine-15 (PBOX-15) is a novel microtubule depolymerization agent that induces cell cycle arrest and subsequent apoptosis in a number of cancer cell lines. Chronic lymphocytic leukemia (CLL) is characterized ...
Modulation of human uterine smooth muscle cell collagen contractility by thrombin, y-27632, tnf alpha and indomethacin
(Springer Nature, 2009-01-01)
Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not ...
Ionizing radiation-dependent and independent phosphorylation of the 32-kda subunit of replication protein a during mitosis
(Oxford University Press (OUP), 2009-08-11)
The human single-stranded DNA-binding protein, replication protein A (RPA), is regulated by the N-terminal phosphorylation of its 32-kDa subunit, RPA2. RPA2 is hyperphosphorylated in response to various DNA-damaging agents ...
Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level
(BMJ, 2009-04-02)
Objective: Achieving joint regeneration in rheumatoid arthritis (RA) represents a future challenge. Autologous synovial mesenchymal stem cells (MSCs) could be therapeutically exploited. However, the inflammatory milieu in ...