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Dn2 thymocytes activate a specific robust dna damage response to ionizing radiation-induced dna double-strand breaks
(Frontiers Media SA, 2018-06-11)
For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it ...
A stromal cell free culture system generates mouse pro-t cells that can reconstitute t-cell compartments in vivo
(Wiley-Blackwell, 2014-12-16)
T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture ...