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Loss of plakophilin 2 disrupts heart development in zebrafish
(UPV/EHU Press, 2012-01-01)
The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. To investigate loss ...
Perk regulated mir-424(322)-503 cluster fine-tunes activation of ire1 and atf6 during unfolded protein response
(Springer Nature, 2015-12-17)
The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...