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Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-tnfα drug
(Elsevier BV, 2015-09-01)
Distinct mechanisms underlie oral vs aboral regeneration in the cnidarianhydractinia echinata
(eLife Sciences Organisation, Ltd., 2015-04-17)
Cnidarians possess remarkable powers of regeneration, but the cellular and molecular mechanisms underlying this capability are unclear. Studying the hydrozoan Hydractinia echinata we show that a burst of stem cell proliferation ...
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
(Springer Nature, 2015-08-25)
Introduction: Conventionally cultured mouse bone marrow mesenchymal stromal cells (mBM-MSC) are a heterogeneous population that often initially contain contaminating haematopoietic cells. Variability in isolation methods, ...
Evolution of a research field—a micro (rna) example
(PeerJ, 2015-03-17)
Background. Every new scientific field can be traced back to a single, seminal publication. Therefore, a bibliometric analysis can yield significant insights into the history and potential future of a research field. This ...
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
(Oxford University Press (OUP), 2015-02-04)
We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 ...
Perk regulated mir-424(322)-503 cluster fine-tunes activation of ire1 and atf6 during unfolded protein response
(Springer Nature, 2015-12-17)
The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted ...
A circulating microrna signature as a biomarker for prostate cancer in a high risk group
(MDPI AG, 2015-07-07)
Introduction: Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs ...
Common genetic variants influence human subcortical brain structures
(Springer Nature, 2015-01-21)
The highly complex structure of the human brain is strongly shaped by genetic influences(1). Subcortical brain regions form circuits with cortical areas to coordinate movement(2), learning, memory(3) and motivation(4), and ...
Disaggregating polyploidy, parental genome dosage and hybridity contributions to heterosis in arabidopsis thaliana
(Wiley-Blackwell, 2015-09-23)
Heterosis is the phenomenon whereby hybrid offspring of genetically divergent parents display superior characteristics compared with their parents. Although hybridity and polyploidy can influence heterosis in hybrid plants, ...
The role of c1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during helicobacter pylori infection
(Springer Nature, 2015-09-08)
Background: Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, ...