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Meta-analysis confirms bcl2 is an independent prognostic marker in breast cancer
(Springer Nature, 2008-05-29)
Background: A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed ...
Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1
(Oxford University Press (OUP), 2008-03-01)
The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest ...
Mesenchymal stem cells expressing trail lead to tumour growth inhibition in an experimental lung cancer model
(Wiley-Blackwell, 2008-03-29)
Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the ...
A non-apoptotic role for caspase-9 in muscle differentiation
(The Company of Biologists, 2008-10-28)
Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ...
Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment
(Wiley-Blackwell, 2008-05-01)
The application of mesenchyrnal stem cells (MSCs) for myocardial repair following ischemic injury is of strong interest, but current knowledge regarding the survival and retention of differentiation potency of stem cells ...
Caspases as therapeutic targets
(Wiley-Blackwell, 2008-09-01)
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; ...
Cytokine-induced β-cell apoptosis is no-dependent, mitochondria-mediated and inhibited by bcl-xl
(Wiley-Blackwell, 2008-04-01)
Pro-inflammatory cytokines are implicated as the main mediators of beta-cell death during type 1 diabetes but the exact mechanisms remain unknown. This study examined the effects of interleukin-1 beta (IL-1 beta), ...
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
(Wiley-Blackwell, 2008-07-10)
Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ...