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The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
(Wiley-Blackwell, 2009-06-04)
During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed ...