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Enhancement of estrogen receptor transcriptional activity by the coactivator grip-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology
(American Society for Biochemistry & Molecular Biology (ASBMB), 1998-03-20)
The human estrogen receptor (ER) contains two major activation functions (AFs) responsible for its transcriptional activity. One of these, activation function 2 (AF-2), located within the hormone-binding domain (HBD), has ...