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Enhanced antitumor efficacy of a dr5-specific trail variant over recombinant human trail in a bioluminescent ovarian cancer xenograft model
(American Association for Cancer Research (AACR), 2009-03-10)
Purpose: Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) is clinically evaluated as novel anticancer drug. rhTRAIL-DR5, a rhTRAIL variant that specifically binds to DR5 receptor, has ...