Browsing University of Galway Support Services by Subject "53bp1"
Now showing items 1-3 of 3
-
A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
(The Royal Society, 2016-09-01)Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions. Here, we provide evidence supporting a ... -
Co-mutation of histone h2ax s139a with y142a rescues y142a-induced ionising radiation sensitivity
(Wiley-Blackwell, 2012-01-01) -
Msl2 is a novel component of the vertebrate dna damage response
(Public Library of Science (PLoS), 2013-07-09)hMSL2 (male-specific lethal 2, human) is a RING finger protein with ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription regulation ...