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dc.contributor.authorMcDermott, Barry
dc.contributor.authorMcGinley, Brian
dc.contributor.authorKrukiewicz, Katarzyna
dc.contributor.authorDivilly, Brendan
dc.contributor.authorJones, Marggie
dc.contributor.authorBiggs, Manus
dc.contributor.authorO'Halloran, Martin
dc.contributor.authorPorter, Emily
dc.date.accessioned2018-08-20T08:46:51Z
dc.date.issued2017-11-27
dc.identifier.citationBarry, McDermott, Brian, McGinley, Katarzyna, Krukiewicz, Brendan, Divilly, Marggie, Jones, Manus, Biggs, Martin, O’Halloran, Emily, Porter. (2018). Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography. Biomedical Physics & Engineering Express, 4(1), 015003.en_IE
dc.identifier.issn2057-1976
dc.identifier.urihttp://hdl.handle.net/10379/7512
dc.description.abstractObjective. To develop dielectrically accurate, easy to mould solid tissue-mimicking materials (TMMs) for use with electrical impedance tomography (EIT) and combine them into a head phantom with realistic anatomy and adjustable pathological lesions. Methods. The conductivity profiles of fat and blood, which span those of most biological tissues, along with aggregate models of the tissues of the head external to the brain, the tissues of the brain, and the cerebellum are identified across the 1 kHz-1 MHz band. TMM mixtures made from polyurethane, graphite, carbon black and either acetone or isopropanol are fabricated to emulate the conductivity profiles of the reference tissues. 3D-printed anatomically realistic moulds of the head and brain are used to cast a two-layer head and brain phantom with cylindrical holes left to allow addition of phantom pathological lesions such as haemorrhages. Results. The TMM spans a wide biological range of fat to blood and is adjustable to match any target tissue. Uniquely, the material is mechanically stable and easy to mould. The fabricated head phantom has excellent anatomic realism, and can represent a healthy brain or one with pathological lesions. The added lesions are easy to adjust in terms of size, shape, and material properties. Conclusion. The presented TMM scan be used to fabricate realistic phantoms for use in EIT studies of most tissue sets. Significance. These TMM sare an important development in phantom technology for EIT; the sample head phantom demonstrates the value and flexibility of the TMMs.en_IE
dc.description.sponsorshipThe research leading to these results has received funding from the European Research Council under the European Union's Horizon 2020 Programme/ERC Grant Agreement BioElecPro n.637780, Science Foundation Ireland (SFI) grant number 15/ERCS/3276, and the Hardiman Research Scholarship from NUIG.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherIOP Publishingen_IE
dc.relation.ispartofBiomedical Physics & Engineering Expressen
dc.subjectConductivityen_IE
dc.subjectEITen_IE
dc.subjectStable tissue-mimickingen_IE
dc.subjectElectrical impedance tomographyen_IE
dc.titleStable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomographyen_IE
dc.typeArticleen_IE
dc.date.updated2018-08-15T17:12:55Z
dc.identifier.doi10.1088/2057-1976/aa922d
dc.local.publishedsourcehttps://doi.org/10.1088/2057-1976/aa922den_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderEuropean Research Councilen_IE
dc.contributor.funderHorizon 2020en_IE
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderHardiman Research Scholarship, NUI Galwayen_IE
dc.description.embargo2018-11-27
dc.internal.rssid14792794
dc.local.contactBarry Mc Dermott, Translational Medical Device Lab, , 2nd Floor Lambe Translational Research Facility,, University College Hospital, , Galway. - Email: b.mcdermott3@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI ERC Support Programme/15/ERCS/3276/IE/BIOELECPRO: Frontier Research on the Dielectric Properties of Biological Tissue/en_IE
dcterms.projectinfo:eu-repo/grantAgreement/EC/H2020::ERC::ERC-STG/637780/EU/Frontier Research on the Dielectric Properties of Biological Tissue/BIOELECPRO
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