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Bipolar disorder and gender are associated with frontolimbic and basal ganglia dysconnectivity: A study of topological variance using network analysis
(Mary Ann Liebert, 2019-12-16)
Well-established structural abnormalities, mostly involving the limbic system, have been associated with disorders of emotion regulation. Understanding the arrangement and connections of these regions with other functionally ...
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
(Elsevier, 2019-11-03)
Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ...
Neuroanatomical dysconnectivity underlying cognitive deficits in bipolar disorder
(Elsevier, 2019-09-18)
BACKGROUND: Graph theory applied to brain networks is an emerging approach to understanding the brain's topological associations with human cognitive ability. Despite well-documented cognitive impairments in bipolar disorder ...
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
(Bentham Science Publishers, 2017)
Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ...
Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations
(SAGE Publications, 2019-11-03)
The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ...
Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
(Elsevier, 2019-09-07)
Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ...
Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation
(Elsevier, 2013-05-16)
Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...
Am I being watched? The role of researcher presence on toddlers’ behaviour during ‘everyday’ pain experiences: a pilot study
(Taylor & Francis, 2019-12-31)
Objective: Paediatric research on 'everyday' pain experiences is sparse, stemming from a lack of appropriate methodologies. We explored the feasibility of two methodologies for conducting naturalistic observations of ...
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
(Elsevier, 2017-02-22)
Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ...
Relationship between epithelial and stromal TRIM28 expression predicts survival in colorectal cancer patients
(Wiley, 2013-02-21)
Background and Aim
TRIM28 is a multi‐domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role ...