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Pharmacological blockade of PPAR isoforms increases conditioned fear responding in the presence of nociceptive tone
(MDPI, 2020-02-24)
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPAR¿, PPARß/¿, PPAR¿) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear ...
A mixed-methods exploration of the educational climate and safety climate during the first year of clinical practice in Ireland
(Lippincott, Williams & Wilkins, 2019-11)
Purpose
Educational climate (EC) and safety climate (SC) are key determinants of residents’ professional development. The goal of this study was to gather longitudinal EC data and data on perceptions of SC in residency, ...
A systematic review of 7 years of research on entrustable professional activities in graduate medical education, 2011–2018
(Wiley, 2019-01-04)
Purpose
This review aimed to synthesise some of the extant work on the use of entrustable professional activities (EPAs) for postgraduate physicians, to assess the quality of the work and provide direction for future ...
Hand hygiene compliance in the intensive care unit: A systematic review
(Lippincott, Williams & Wilkins, 2019-09)
Abstract
Objectives:
To synthesize the literature describing compliance with World Health Organization hand hygiene guidelines in ICUs, to evaluate the quality of extant research, and to examine differences in compliance ...
ASPiH Conference 2019 keynote paper. Quality improvement through simulation: a missed opportunity?
(BMJ Publishing Group, 2020-03-04)
As the use of simulation has become more established in the delivery of healthcare education and training, there has been a corresponding increase in healthcare simulation research. Simulation-based research can be divided ...
Storage of blood clots for histological analysis: How long is too long in saline and paraformaldehyde?
(Universidad de Murcia, 2019)
To investigate the composition of blood clots following mechanical thrombectomy, it is essential to ensure optimum storage for highest quality histological and immunofluorescence analysis. We investigated for how long clots ...
Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications
(Wiley, 2012-01-30)
Mesenchymal stem cells (MSCs) are nonhematopoietic multipotent adult stem cells. They have been shown to have a natural tropism for many tumors types, including colorectal, and are capable of escaping host immune surveillance. ...
Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment
(BMC (part of Springer Nature), 2018-04-10)
Background
Stromal gene expression patterns predict patient outcomes in colorectal cancer. TRIM28 is a transcriptional co-repressor that regulates an abundance of genes through the KRAB domain family of transcription ...
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer
(Wiley, 2014-11-13)
Ceramide synthase 5 is involved in the de novo synthesis of ceramide, a sphingolipid involved in cell death and proliferation. In this study, we investigated the role of ceramide synthase 5 in colorectal cancer by examining ...
Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity
(Elsevier, 2017-01-30)
Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ...