Browsing School of Medicine by Author "http://dx.doi.org/10.13039/501100008530"

Now showing items 1-20 of 24

    • The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome 

      Rossi, Rosanna; Fitzgerald, Sean; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Pandit, Abhay; Santos, Andreia M. Silva; Murphy, Blathnaid; Alderson, Jack; Brennan, Paul; Power, Sarah; O'Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Psychogios, Klearchos; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, Andras; Vadasz, Agnes; Szikora, Istvan; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2020-09-16)
      Both intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) are evidence-based treatments for acute ischemic stroke (AIS) in selected cases. Recanalization may occur following IVT without the necessity of further ...

    • Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design 

      Shearer, J. Andrew; Douglas, Andrew S.; Kirby, B. P.; Tatlisumak, Turgut; Doyle, Karen M. (Bentham Science Publishers, 2017)
      Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ...

    • Artificial cornea: Past, current, and future directions 

      Holland, Gráinne; Pandit, Abhay; Sánchez-Abella, Laura; Haiek, Andrea; Loinaz, Iraida; Dupin, Damien; Gonzalez, Maria; Larra, Eva; Bidaguren, Aritz; Lagali, Neil; Moloney, Elizabeth B.; Ritter, Thomas (Frontiers Media, 2021-11-12)
      Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal ...

    • Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization 

      Rossi, Rosanna; Fitzgerald, Seán; Molina Gil, Sara; Mereuta, Oana; Douglas, Andrew; Pandit, Abhay; Brennan, Paul; Power, Sarah; Alderson, Jack; O'Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Psychogios, Klearchos; Magoufis, George; Tsivgoulis, Georgios; Szikora, Istvan; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen (SAGE Publications, 2021-07-07)
      Introduction We assessed the correlation between thrombus size before and after mechanical thrombectomy, measured as length by Computed Tomography Angiography/Non-Contrast Computed Tomography (CTA/NCCT) and Extracted Clot ...

    • Detection, diagnosis and treatment of acute ischemic stroke: Current and future perspectives 

      Patil, Smita; Rossi, Rosanna; Jabrah, Duaa; Doyle, Karen (Frontiers Media, 2022-06-24)
      Stroke is one of the leading causes of disability worldwide. Early diagnosis and treatment of stroke are important for better clinical outcome. Rapid and accurate diagnosis of stroke subtypes is critical. This review ...

    • Differential role of anterior cingulate cortical glutamatergic neurons in pain-related aversion learning and nociceptive behaviors in male and female rats 

      Jarrin, Sarah; Pandit, Abhay; Roche, Michelle; Finn, David P. (Frontiers Media, 2020-08-11)
      Pain is comprised of both sensory and affective components. The anterior cingulate cortex (ACC) is a key brain region involved in the emotional processing of pain. Specifically, glutamatergic transmission within the ACC ...

    • Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry 

      Rossi, Rosanna; Molina, Sara; Mereuta, Oana Madalina; Douglas, Andrew; Fitzgerald, Seán; Tierney, Ciara; Pandit, Abhay; Brennan, Paul; Power, Sarah; O’Hare, Alan; Gilvarry, Michael; McCarthy, Ray; Magoufis, Georgios; Tsivgoulis, Georgios; Nagy, András; Vadász, Ágnes; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dunker, Dennis; Carlqvist, Jeanette; Psychogios, Klearchos; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Springer, 2021-08-20)
      Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT ...

    • Extracellular vesicles as modulators of wound healing 

      Cabral, Joana; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Elsevier, 2018-01-31)
      Impaired healing of cutaneous wounds and ulcers continues to have a major impact on the quality of life of millions of people. In recent years, the capacity for stem and progenitor cells to promote wound repair has been ...

    • Histological stroke clot analysis after thrombectomy: Technical aspects and recommendations 

      Staessens, S.; Fitzgerald, Seán; Andersson, T.; Clarencon, F.; Denorme, F.; Gounis, M. J.; Hacke, W.; Liebeskind, D. S.; Szikora, I.; van Es, A. C. G. M.; Brinjikji, W.; Doyle, Karen M.; De Meyer, S. F. (SAGE Publications, 2019-11-03)
      The recent advent of endovascular procedures has created the unique opportunity to collect and analyze thrombi removed from cerebral arteries, instigating a novel subfield in stroke research. Insights into thrombus ...

    • Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies 

      Wang, Jiemin; Donohoe, Ellen; Canning, Aoife; Moosavizadeh, Seyedmohammad; Buckley, Fiona; Brennan, Meadhbh Á.; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2023-10-23)
      Background Mesenchymal stromal cells (MSCs) show great potential for immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for the treatment of Type 1 diabetes, graft-versus-host disease ...

    • Large artery atherosclerotic clots are larger than clots of other stroke etiologies and have poorer recanalization rates 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Molina, Sara; Okolo, Adaobi; Douglas, Andrew; Jabrah, Duaa; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Ceder, Erik; Dehlfors, Niclas; Dunker, Dennis; Nordanstig, Annika; Redfors, Petra; Jood, Katarina; Magoufis, Georgios; Psychogios, Klearchos; Tsivgoulis, Georgios; Alderson, Jack; O’Hare, Alan; Power, Sarah; Brennan, Paul; Nagy, András; Vadász, Ágnes; Brinjikji, Waleed; Kallmes, David; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (Elsevier, 2020-11-24)
      Objectives There is a paucity of knowledge in the literature relating to the extent of clot burden and stroke etiology. In this study, we measured the Extracted Clot Area (ECA) retrieved during endovascular treatment (EVT) ...

    • Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing 

      Fitzgerald, Seán; Liu, Yang; Dai, Daying; Mereuta, Oana Madalina; Abbasi, Mehdi; Larco, JL Arturo; Douglas, Andrew; Kallmes, David; Savastano, Luis; Doyle, Karen M.; Brinjikji, Waleed (American Society of Neuroradiology, 2021-04-08)
      BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot analogs for in vitro endovascular device testing using animal blood of various species. Blood components vary greatly among species; therefore, ...

    • Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Murphree Jr, Dennis H.; Pandit, Abhay; Douglas, Andrew; Rizvi, Asim; Kadirvel, Ramanathan; Gilvarry, Michael; McCarthy, Ray; Stritt, Manuel; Gounis, Matthew J.; Brinjikji, Waleed; Kallmes, David F.; Doyle, Karen M. (Public Library of Science, 2019-12-05)
      Our aim was to assess the utility of a novel machine learning software (Orbit Image Analysis) in the histological quantification of acute ischemic stroke (AIS) clots. We analyzed 50 AIS blood clots retrieved using mechanical ...

    • The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse. 

      Bahri, Ola A.; Naldaiz-Gastesi, Neia; Kennedy, Donna C.; Wheatley, Antony M.; Izeta, Ander; McCullagh, Karl J. A. (Nature Research, 2019-11-04)
      The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis. Given ...

    • Per pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted-clot-area and histological composition 

      Fitzgerald, Seán; Rossi, Rosanna; Mereuta, Oana Madalina; Jabrah, Duaa; Okolo, Adaobi; Douglas, Andrew; Molina Gil, Sara; Pandit, Abhay; McCarthy, Ray; Gilvarry, Michael; Dunker, Dennis; Nordanstig, Annika; Ceder, Erik; Redfors, Petra; Jood, Katarina; Dehlfors, Niclas; Magoufis, Georgios; Tsivgoulis, Georgios; Brinjikji, Waleed; Kallmes, David F.; Hare, Alan; Power, Sarah; Brennan, Paul; Alderson, Jack; Nagy, András; Vadász, Ágnes; Psychogios, Klearchos; Szikora, Istvan; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Doyle, Karen M. (BMJ Publishing Group, 2020-12-09)
      Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic ...

    • Platelet-rich clots as identified by Martius Scarlet Blue staining are isodense on NCCT 

      Fitzgerald, Seán; Wang, Shunli; Dai, Daying; Douglas, Andrew; Kadirvel, Ramanathan; Gounis, Matthew J.; Chueh, Juyu; Puri, Ajit S.; Layton, Kennith F.; Thacker, Ike C.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Almekhlafi, Mohammed A.; Demchuk, Andrew M.; Nogueira, Raul G.; Pereira, Vitor M.; Kvamme, Peter; Kayan, Yasha; Delgado Almandoz, Josser E.; Yoo, Albert J.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (BMJ Publishing Group, 2019-04-05)
      Background Current studies on clot characterization in acute ischemic stroke focus on fibrin and red blood cell composition. Few studies have examined platelet composition in acute ischemic stroke clots. We characterize ...

    • Platelet-rich emboli in cerebral large vessel occlusion are associated with a large artery atherosclerosis source 

      Fitzgerald, Seán; Dai, Daying; Wang, Shunli; Douglas, Andrew; Kadirvel, Ramanathan; Layton, Kennith F.; Thacker, Ike C.; Gounis, Matthew J.; Chueh, Ju-Yu; Puri, Ajit S.; Almekhlafi, Mohammed; Demchuk, Andrew M.; Hanel, Ricardo A.; Sauvageau, Eric; Aghaebrahim, Amin; Yoo, Albert J.; Kvamme, Peter; Pereira, Vitor M.; Kayan, Yasha; Delgado Almandoz, Josser E.; Nogueira, Raul G.; Rabinstein, Alejandro A.; Kallmes, David F.; Doyle, Karen M.; Brinjikji, Waleed (American Heart Association, 2019-05-29)
      Background and Purpose— Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source. We assessed histological clot composition in a series of patients with large vessel occlusion and ...

    • Potential biomarkers of acute ischemic stroke etiology revealed by mass spectrometry based proteomic characterization of formalin-fixed paraffin-embedded blood clots 

      Rossi, Rosanna; Mereuta, Oana Madalina; Barbachan e Silva, Mariel; Molina Gil, Sara; Douglas, Andrew; Pandit, Abhay; Gilvarry, Michael; McCarthy, Ray; O'Connell, Shane; Tierney, Ciara; Psychogios, Klearchos; Tsivgoulis, Georgios; Szikora, István; Tatlisumak, Turgut; Rentzos, Alexandros; Thornton, John; Ó Broin, Pilib; Doyle, Karen M. (Frontiers Media, 2022-04-19)
      Background and Aims: Besides the crucial role in the treatment of acute ischemic stroke (AIS), mechanical thrombectomy represents a unique opportunity for researchers to study the retrieved clots, with the possibility of ...

    • Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models 

      Fitzgerald, Seán; Ryan, David; Thornton, John; Nogueira, Raul G. (BMJ Publishing Group, 2020-06-30)
      Background Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. Objective To evaluate the navigability and clot retrieval performance of a ...

    • S100b in acute ischemic stroke clots is a biomarker for post-thrombectomy intracranial hemorrhages 

      Rossi, Rosanna; Douglas, Andrew; Molina Gil, Sara; Jabrah, Duaa; Pandit, Abhay; Gilvarry, Michael; McCarthy, Ray; Prendergast, James; Jood, Katarina; Redfors, Petra; Nordanstig, Annika; Ceder, Erik; Dunker, Dennis; Carlqvist, Jeanette; Szikora, István; Thornton, John; Tsivgoulis, Georgios; Psychogios, Klearchos; Tatlisumak, Turgut; Rentzos, Alexandros; Doyle, Karen M. (Frontiers Media, 2023-01-23)
      Background and purpose: Post-thrombectomy intracranial hemorrhages (PTIH) are dangerous complications of acute ischemic stroke (AIS) following mechanical thrombectomy. We aimed to investigate if S100b levels in AIS clots ...