Browsing School of Medicine by Author "http://dx.doi.org/10.13039/501100002081"
Now showing items 1-15 of 15
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Bipolar disorder and gender are associated with frontolimbic and basal ganglia dysconnectivity: A study of topological variance using network analysis
Nabulsi, Leila; McPhilemy, Genevieve; Kilmartin, Liam; O'Hora, Denis; O'Donoghue, Stefani; Forcellini, Giulia; Najt, Pablo; Ambati, Srinath; Costello, Laura; Byrne, Fintan; McLoughlin, James; Hallahan, Brian; McDonald, Colm; Cannon, Dara M. (Mary Ann Liebert, 2019-12-16)Well-established structural abnormalities, mostly involving the limbic system, have been associated with disorders of emotion regulation. Understanding the arrangement and connections of these regions with other functionally ... -
Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
Okine, Bright N.; Gaspar, Jessica C.; Madasu, Manish K.; Olango, Weredeselam M.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2016-12-01)The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling ... -
Chondrocytes derived from mesenchymal stromal cells and induced pluripotent cells of patients with familial osteochondritis dissecans exhibit an endoplasmic reticulum stress response and defective matrix assembly
Xu, Maojia; Stattin, Eva-Lena; Shaw, Georgina; Heinegård, Dick; Sullivan, Gareth; Wilmut, Ian; Colman, Alan; Önnerfjord, Patrik; Khabut, Areej; Aspberg, Anders; Dockery, Peter; Hardingham, Timothy; Murphy, Mary; Barry, Frank (Wiley, 2016-07-07)Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is ... -
Frontolimbic, frontoparietal, and default mode involvement in functional dysconnectivity in psychotic bipolar disorder
Nabulsi, Leila; McPhilemy, Genevieve; Kilmartin, Liam; Whittaker, Joseph R.; Martyn, Fiona M.; Hallahan, Brian; McDonald, Colm; Murphy, Kevin; Cannon, Dara M. (Elsevier, 2019-11-11)BACKGROUND: Functional abnormalities, mostly involving functionally specialized subsystems, have been associated with disorders of emotion regulation such as bipolar disorder (BD). Understanding how independent functional ... -
Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey
Madasu, Manish K.; Okine, Bright N.; Olango, Weredeselam M.; Rea, Kieran; Lenihan, Róisín; Roche, Michelle; Finn, David P. (Elsevier, 2016-08-09)Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, ... -
The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse.
Bahri, Ola A.; Naldaiz-Gastesi, Neia; Kennedy, Donna C.; Wheatley, Antony M.; Izeta, Ander; McCullagh, Karl J. A. (Nature Research, 2019-11-04)The dermal striated muscle panniculus carnosus (PC), prevalent in lower mammals with remnants in humans, is highly regenerative, and whose function is purported to be linked to defence and shivering thermogenesis. Given ... -
Pharmacological blockade of PPAR isoforms increases conditioned fear responding in the presence of nociceptive tone
Gaspar, Jessica C.; Okine, Bright N.; Llorente-Berzal, Alvaro; Roche, Michelle; Finn, David P. (MDPI, 2020-02-24)Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with three isoforms (PPAR¿, PPARß/¿, PPAR¿) and can regulate pain, anxiety, and cognition. However, their role in conditioned fear and pain-fear ... -
PPARs and pain
Okine, Bright N.; Gaspar, Jessica C.; Finn, David P. (Wiley, 2018-04-21)Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or ... -
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
Rea, Kieran; McGowan, Fiona; Corcoran, Louise; Roche, Michelle; Finn, David P. (Wiley, 2018-05-30)Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ... -
Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains
Jennings, Elaine M.; Okine, Bright N.; Olango, Weredeselam M.; Roche, Michelle; Finn, David P. (Elsevier, 2015-05-16)Repeated exposure to a homotypic stressor such as forced swimming enhances nociceptive responding in rats. However, the influence of genetic background on this stress-induced hyperalgesia is poorly understood. The aim of ... -
Shiga toxigenic Escherichia coli incidence is related to small area variation in cattle density in a region in Ireland
Brehony, Carina; Cullinan, John; Cormican, Martin; Morris, D. (Elsevier, 2018-05-12)Shiga toxigenic Escherichia coli (STEC) are pathogenic E. coli that cause infectious diarrhoea. In some cases infection may be complicated by renal failure and death. The incidence of human infection with STEC in Ireland ... -
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
O'Malley, Grace; Treacy, Oliver; Lynch, Kevin; Naicker, Serika D.; Leonard, Niamh A.; Lohan, Paul; Dunne, Philip D.; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (American Association for Cancer Research, 2018-11)Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ... -
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ... -
Supraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disorders
Madasu, M.K.; Roche, Michelle; Finn, David P. (Karger, 2015)The transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for ... -
A systematic review of the use of positive deviance approaches in primary care
O’Malley, Roisin; O'Connor, Paul; Madden, Caoimhe; Lydon, Sinéad (Oxford University Press, 2021-11-25)Abstract Background: The Positive Deviance (PD) approach focuses on identifying and learning from those who demonstrate exceptional performance despite facing similar resource constraints to others. Recently, it has been ...