Browsing School of Medicine by Author "http://dx.doi.org/10.13039/501100001588"
Now showing items 1-5 of 5
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Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
Shearer, J. Andrew; Douglas, Andrew S.; Kirby, B. P.; Tatlisumak, Turgut; Doyle, Karen M. (Bentham Science Publishers, 2017)Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ... -
Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity
O'Kennedy, Richard; Fitzgerald, Seán; Murphy, Caroline (Elsevier, 2017-01-30)Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ... -
Maximizing the catheter-to-vessel size optimizes distal flow control resulting in improved revascularization in vitro for aspiration thrombectomy
Nogueira, Raul G.; Ryan, David; Mullins, Liam; Thornton, John; Fitzgerald, Seán (BMJ Publishing Group, 2021-03-15)Background Balloon guide catheters (BGCs) achieve proximal flow control during thrombectomy but antegrade intracranial flow often persists via the Circle of Willis. Closely sizing an aspiration catheter to the target vessel ... -
Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing
Fitzgerald, Seán; Liu, Yang; Dai, Daying; Mereuta, Oana Madalina; Abbasi, Mehdi; Larco, JL Arturo; Douglas, Andrew; Kallmes, David; Savastano, Luis; Doyle, Karen M.; Brinjikji, Waleed (American Society of Neuroradiology, 2021-04-08)BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot analogs for in vitro endovascular device testing using animal blood of various species. Blood components vary greatly among species; therefore, ... -
Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models
Fitzgerald, Seán; Ryan, David; Thornton, John; Nogueira, Raul G. (BMJ Publishing Group, 2020-06-30)Background Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. Objective To evaluate the navigability and clot retrieval performance of a ...