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Now showing items 31-40 of 56
Providing care for a person with late-stage dementia at home: What are carers' experiences?
(SAGE Publications, 2018-05-10)
Background
It is widely reported that carers who provide care for a family member with dementia endure physical and psychological burdens. Not only do they fulfil an important role for the person with dementia but also ...
A role for viral infections in Parkinson's etiology?
(Portland Press, 2018-04-16)
Despite over 200 years since its first description by James Parkinson, the cause(s) of most cases of Parkinson’s disease (PD) are yet to be elucidated. The disparity between the current understanding of PD symptomology and ...
Brain repair for Parkinson's disease: is the answer in the matrix?
(Medknow Publications, 2018-07-13)
Two hundred years after James Parkinson first described the cardinal
motor symptoms of the disorder that would later bear his name, there
is still an irrefutable need for a therapy that targets the underlying
pathophysiology ...
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
(Wiley, 2018-05-30)
Background and Purpose
The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ...
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
(Elsevier, 2018-12-13)
Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ...
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
(American Association for Cancer Research, 2018-11)
Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ...
Prevalence and co-variates of burnout in consultant hospital doctors: burnout in consultants in Ireland Study (BICDIS)
(Springer Verlag, 2018-08-20)
Objectives Burnout is prevalent among doctors and affects the quality of patient care. Little research on burnout in consultant-level doctors has been done. The objective of this study was to measure burnout in the hospital ...
Referral of patients to plastic surgeons following self-harm: Opportunities for suicide prevention
(Elsevier, 2018-11-13)
Self-harm is a common source of referral to plastic and hand surgery services. Appropriate management of these patients is complex and includes the need for close liaison with mental health services. Self-harm is the single ...
Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
(Springer Nature, 2018-01-25)
Adult Mesenchymal Stem Cells (MSCs) have a well-established tumor-homing capacity, highlighting potential as tumor-targeted delivery vehicles. MSCs secrete extracellular vesicle (EV)-encapsulated microRNAs, which play a ...
Acute ischemic stroke secondary to cardiac embolus of a ‘foreign body’ material after a redo sternotomy for mitral valve replacement: A case report
(SAGE Publications, 2018-11-14)
Cardiac surgery has been shown to be associated with increased risk of acute ischemic stroke. This report presents a case of a successful mechanical embolectomy procedure to treat a patient for an acute ischemic stroke, ...