Browsing College of Medicine, Nursing and Health Sciences by Author "Alkermes Inc"
Now showing items 1-3 of 3
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Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
Hughes, Edel M.; Thornton, Aoife M.; Kerr, Daniel M.; Smith, Karen; Sanchez, Connie; Kelly, John P.; Finn, David P. (Elsevier, 2020-08-05)The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ... -
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
Burke, Nikita N.; Ferdousi, Mehnaz; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Kelly, John P. (Elsevier, 2018-12-13)Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ... -
Sex differences and similarities in depressive-and anxiety-like behaviour in the Wistar-Kyoto rat
Burke, Nikita N.; Coppinger, Jonathan; Deaver, Daniel R.; Roche, Michelle; Finn, David P.; Kelly, John (Elsevier, 2016-08-31)Depression is a debilitating psychiatric disorder that is highly comorbid with anxiety. Depression is twice as prevalent in women as in men, however, females remain underrepresented in preclinical research. The stress ...