Browsing Externally hosted open access publications with University of Galway authors (1) by Subject "s-phase"

Now showing items 1-6 of 6

    • Coordinated regulation of replication protein a activities by its subunits p14 and p32 

      Weisshart, Klaus; Pestryakov, Pavel; Smith, Richard W. P.; Hartmann, Hella; Kremmer, Elisabeth; Lavrik, Olga; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-06-17)
      The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive analyses, the functions of the smallest RPA subunit p14 are still ...

    • Distinctive activities of dna polymerases during human dna replication 

      Rytkonen, Anna K.; Vaara, Markku; Nethanel, Tamar; Kaufmann, Gabriel; Sormunen, Raija; Laara, Esa; Nasheuer, Heinz-Peter; Rahmeh, Amal; Lee, Marietta Y. W. T.; Syvaoja, Juhani E.; Pospiech, Helmut (Wiley-Blackwell, 2006-07-01)
      The contributions of human DNA polymerases (pols) alpha, delta and epsilon during S-phase progression were studied in order to elaborate how these enzymes co-ordinate their functions during nuclear DNA replication. Pol ...

    • Dna polymerase ε associates with the elongating form of rna polymerase ii and nascent transcripts 

      Rytkönen, Anna K.; Hillukkala, Tomi; Vaara, Markku; Sokka, Miiko; Jokela, Maarit; Sormunen, Raija; Nasheuer, Heinz-Peter; Nethanel, Tamar; Kaufmann, Gabriel; Pospiech, Helmut; Syväoja, Juhani E. (Wiley-Blackwell, 2006-11-15)
      DNA polymerase epsilon co-operates with polymerases alpha and delta in the replicative DNA synthesis of eukaryotic cells. We describe here a specific physical interaction between DNA polymerase epsilon and RNA polymerase ...

    • Double-strand breaks trigger mrx- and mec1-dependent, but tel1-independent, checkpoint activation 

      Grenon, Muriel; Magill, Christine P.; Lowndes, Noel F.; Jackson, Stephen P. (Oxford University Press (OUP), 2006-08-01)
      Together with the Tel1 PI3 kinase, the Mre11/Rad50/Xrs2 (MRX) complex is involved in checkpoint activation in response to double-strand breaks (DSBs), a function also conserved in human cells by Mre11/Rad50/Nbs1 acting ...

    • Regulation of eukaryotic dna replication at the initiation step 

      Pollok, S.; Stoepel, J.; Bauerschmidt, C.; Kremmer, E.; Nasheuer, Heinz-Peter (Portland Press Ltd., 2003-02-01)
      The studies of cell growth and division have remained at the centre of biomedical research for more than 100 years. The combination of genetic, biochemical, molecular and cell biological techniques recently yielded a burst ...

    • Role of the saccharomyces cerevisiae rad9 protein in sensing and responding to dna damage 

      Toh, G.W.-L.; Lowndes, N.F. (Portland Press Ltd., 2003-02-01)
      Eukaryotic cells have evolved surveillance mechanisms, known as DNA-damage checkpoints, that sense and respond to genome damage. DNA-damage checkpoint pathways ensure co-ordinated cellular responses to DNA damage, including ...