Browsing Externally hosted open access publications with University of Galway authors (1) by Author "Zwacka, R. M."
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Constitutively activated nuclear factor- b, but not induced nf- b, leads to trail resistance by up-regulation of x-linked inhibitor of apoptosis protein in human cancer cells
Braeuer, S. J.; Buneker, C.; Mohr, A.; Zwacka, R. M. (American Association for Cancer Research (AACR), 2006-10-01)The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in most, but not all, cancer cells. The molecular factors regulating the sensitivity to TRAIL are still incompletely ... -
Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells
Behrend, L.; Mohr, A.; Dick, T.; Zwacka, R. M. (American Society for Microbiology, 2005-08-17)The mitochondrial enzyme manganese superoxide dismutase (MnSOD) is known to suppress cell growth in different tumor cell lines. However, the molecular mechanism of this growth-retarding effect is not fully understood. Here ...