Browsing Externally hosted open access publications with University of Galway authors (1) by Author "Samali, Afshin"
Now showing items 1-7 of 7
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Antioxidant-mediated inhibition of the heat shock response leads to apoptosis
Gorman, Adrienne M.; Heavey, Barry; Creagh, Emma; Cotter, Thomas G; Samali, Afshin (Wiley-Blackwell, 1999-02-19) -
Cd95-mediated alteration in hsp70 levels is dependent on protein stabilization
Concannon, Caoimhín G.; FitzGerald, Una; Holmberg, Carina I.; Szegezdi, Eva; Sistonen, Lea; Samali, Afshin (Springer Nature, 2005-01-01)Engagement of death receptors induces caspase activation and apoptosis. A recent study reported altered protein expression, including increased Hsp70 levels during CD95-mediated apoptosis. Here, we examined the mechanism ... -
Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease
Reeve, Janice L. V.; Duffy, Angela M.; O'Brien, Timothy; Samali, Afshin (Wiley-Blackwell, 2005-07-01)Cardiovascular disease is a leading cause of death worldwide. Loss of function or death of cardiomyocytes is a major contributing factor to these diseases. Cell death in conditions such as heart failure and myocardial ... -
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
Kavanagh, Edel T.; Loughlin, John P.; Herbert, Kate Reed; Dockery, Peter; Samali, Afshin; Doyle, Karen M.; Gorman, Adrienne M. (Elsevier BV, 2006-12-01) -
hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli
Samali, Afshin; Robertson, John D.; Peterson, Elisabeth; Manero, Florence; van Zeijl, Leone; Paul, Catherine; Cotgreave, Ian A.; Arrigo, André-Patrick; Orrenius, Sten (Springer Nature, 2001-01-01)Enhanced cell survival and resistance to apoptosis during thermotolerance correlates with an increased expression of heat shock proteins (Hsps). Here we present additional evidence in support of the hypothesis that the ... -
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, Eva; Logue, Susan E; Gorman, Adrienne M.; Samali, Afshin (Wiley-Blackwell, 2006-09-01)The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ... -
Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins
Samali, Afshin; Holmberg, Carina I.; Sistonen, Lea; Orrenius, Sten (Wiley-Blackwell, 1999-11-15)