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dc.contributor.authorKerr, Daniel M.
dc.contributor.authorHenry, Rebecca
dc.contributor.authorRoche, Michelle
dc.date.accessioned2016-05-05T10:12:27Z
dc.date.available2016-05-05T10:12:27Z
dc.date.issued2013-12-20
dc.identifier.citationKerr DM, Henry R, Roche M (2013) 'Anandamide Modulation of Endotoxin-Induced Inflammation' Anatomy and Physiology, 4:e130. doi: 10.4172/2161-0940.1000e130en_IE
dc.identifier.issn2161-0940
dc.identifier.urihttp://hdl.handle.net/10379/5749
dc.description.abstractThe endocannabinoid system is comprised of the CB1 and CB2 receptors, the naturally occurring endogenous ligands, anandamide (AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes involved in their synthesis and degradation. The enzyme fatty acid amide hydrolyase (FAAH) preferentially metabolises AEA, and the related N-acylethanolamines, N-palmitoylethanolamide (PEA) and N-oleoylethanolamide (OEA). While PEA and OEA do not have activity at CB1/2 receptors, they are capable of enhancing AEA signaling by competing with AEA at the catalytic site on the FAAH enzyme. All elements of the endocannabinoid system are widely and densely expressed in the mammalian immune system and brain and as such represent an important therapeutic target for a number of peripheral and central inflammatory disorders [1-3].en_IE
dc.description.sponsorshipScience Foundation Ireland Research Frontiers Project (Grant no. 11/RFP/NES/3175) and the Discipline of Physiology, National University of Ireland Galway.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherOMICS Internationalen_IE
dc.relation.ispartofAnatomy and Physiologyen
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/ie/
dc.titleAnandamide modulation of endotoxin-induced inflammationen_IE
dc.typeArticleen_IE
dc.date.updated2016-04-22T15:26:46Z
dc.identifier.doi10.4172/2161-0940.1000e130
dc.local.publishedsourcehttp://www.omicsonline.org/open-access/anandamide-modulation-of-endotoxininduced-inflammation-2161-0940.1000e130.php?aid=23483en_IE
dc.description.peer-reviewedNot peer reviewed
dc.contributor.funder|~|
dc.internal.rssid10575303
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland