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dc.contributor.authorHogan, Niamh M.
dc.contributor.authorJoyce, Myles R.
dc.date.accessioned2013-11-20T17:19:03Z
dc.date.available2013-11-20T17:19:03Z
dc.date.issued2012-12-17
dc.identifier.citationHogan NM, Joyce MR, Kerin MJ (2012) 'MicroRNA expression in colorectal cancer'. Cancer Biomarkers, 11 (6):239-243.en_US
dc.identifier.issn1875-8592
dc.identifier.urihttp://hdl.handle.net/10379/3825
dc.descriptionJournal articleen_US
dc.description.abstractColorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth most common cause of death from cancer [10]. Prognosis is heavily linked to stage at diagnosis. The major cause of death is development of metastasis in liver, abdominal lymph nodes,and lung, forwhich there is no cure [21]. According to the most recently defined American Joint Committee on Cancer (AJCC) system for colonic adenocarcinoma, 5-year stage-specific survivals were 93.2% for stage I disease compared with 8.1% for stage IV [34], highlighting a need for novel early detection strategies. Colorectal cancer, at least theoretically, is a disease entity which is amenable to early detection, since it exhibits a stepwise progression of carcinogenesis from benign polyps to adenocarcinoma, over a period of time. The majority of national screening programmes currently centre on the use of colonoscopy or faecal immunohistochemistry/occult blood testing. Colonoscopy is an expensive, invasive procedure which carries a significant risk of intestinal perforation (1:700). Faecal testing ismore cost effective and less invasive but sacrifices sensitivity and specificity. Carcinoembryonic antigen, the only blood test currently available, exhibits low sensitivity and specificity. Hence, there is greatneed for new biomarkers for early detection of CRC.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.publisherIOS Pressen_US
dc.relation.ispartofCancer Biomarkersen
dc.subjectColorectal canceren_US
dc.subjectRNAen_US
dc.titleMicroRNA expression in colorectal cancer.en_US
dc.typeArticleen_US
dc.date.updated2013-08-20T15:08:40Z
dc.identifier.doi10.3233/CBM-2012-00278
dc.local.publishedsourcehttp://dx.doi.org/10.3233/CBM-2012-00278en_US
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid3063927
dc.local.contactMichael Kerin, Dept. Of Surgery, Clinical Science Institute, Nui Galway. 87-4203 Email: michael.kerin@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionPUBLISHED
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