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dc.contributor.authorRea, Kieran
dc.contributor.authorOlango, Weredeselam M.
dc.contributor.authorOkine, Bright N.
dc.contributor.authorMadasu, Manish K.
dc.contributor.authorMcGuire, Iseult C.
dc.contributor.authorCoyle, Kathleen
dc.contributor.authorHarhen, Brendan
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2020-11-02T08:54:12Z
dc.date.available2020-11-02T08:54:12Z
dc.date.issued2014-01
dc.identifier.citationRea, Kieran, Olango, Weredeselam M., Okine, Bright N., Madasu, Manish K., McGuire, Iseult C., Coyle, Kathleen, Harhen, Brendan, Roche, Michelle, Finn, David P. (2014). Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli. PAIN, 155(1), 69-79. doi:10.1016/j.pain.2013.09.012en_IE
dc.identifier.issn0304-3959
dc.identifier.urihttp://hdl.handle.net/10379/16250
dc.description.abstractPain is both a sensory and an emotional experience, and is subject to modulation by a number of factors including genetic background modulating stress/affect. The Wistar-Kyoto (WKY) rat exhibits a stress-hyper-responsive and depressive-like phenotype and increased sensitivity to noxious stimuli, compared with other rat strains. Here, we show that this genotype-dependent hyperalgesia is associated with impaired pain-related mobilisation of endocannabinoids and transcription of their synthesising enzymes in the rostral ventromedial medulla (RVM). Pharmacological blockade of the Cannabinoid(1) (CB1) receptor potentiates the hyperalgesia in WKY rats, whereas inhibition of the endocannabinoid catabolising enzyme, fatty acid amide hydrolase, attenuates the hyperalgesia. The latter effect is mediated by CB1 receptors in the RVM. Together, these behavioural, neurochemical, and molecular data indicate that impaired endocannabinoid signalling in the RVM underpins hyper-responsivity to noxious stimuli in a genetic background prone to heightened stress/affect. (C) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.en_IE
dc.description.sponsorshipThis work was supported by a research grant from Science 653 Foundation Ireland (10/IN.1/B2976)en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherInternational Association for the Study of Painen_IE
dc.relation.ispartofPainen
dc.subjectACID AMIDE HYDROLASEen_IE
dc.subjectFEAR-CONDITIONED ANALGESIAen_IE
dc.subjectCANNABINOID RECEPTOR AGONISTen_IE
dc.subjectSTRESS-INDUCED ANALGESIAen_IE
dc.subjectFAAH INHIBITOR URB597en_IE
dc.subjectHIGH-ANXIETY RATSen_IE
dc.subjectBRAIN-STEMen_IE
dc.subjectMOLECULAR CHARACTERIZATIONen_IE
dc.subjectBASOLATERAL AMYGDALAen_IE
dc.subjectINFLAMMATORY PAINen_IE
dc.titleImpaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimulien_IE
dc.typeArticleen_IE
dc.date.updated2020-10-30T01:51:01Z
dc.identifier.doi10.1016/j.pain.2013.09.012
dc.local.publishedsourcehttps://dx.doi.org/10.1016/j.pain.2013.09.012en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.internal.rssid16219841
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B2976/IE/The role of the endocannabinoid system in anxiety-induced modulation of pain: sites and mechanisms of action/en_IE
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