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Mannosylated Polyethyleneimine-Hyaluronan Nanohybrids for Targeted Gene Delivery to Macrophage-Like Cell Lines
(American Chemical Society, 2012-05-02)
Nonviral gene delivery systems have a number of limitations including low transfection efficiency, specificity, and cytotoxicity, especially when the target cells are macrophages. To address these issues, the hypothesis ...
Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D "Knot" Polymer Structure for Nonviral Gene Delivery
(American Chemical Society, 2012-02-12)
The large research effort focused on enhancing nonviral transfection vectors has clearly demonstrated that their macromolecular structure has a significant effect on their transfection efficacy. The 3D branched polymeric ...
A review of phosphorus and sediment release from Irish tillage soils, the methods used to quantify losses and the current state of mitigation practice.
(2012)
Throughout the European Union (EU), agricultural soils with high phosphorus (P) status due to a surplus input of fertiliser have been identified as a landscape pressure impacting on water quality. In the Republic of Ireland, ...
A Biomaterial Approach to Peripheral Nerve Regeneration: Bridging the Peripheral Nerve Gap and Enhancing Functional Recovery
(The Royal Society, 2011-11)
Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative 'hollow nerve guidance conduits (NGCs)' have a number of ...
Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions
(Springer, 2010-11)
Anisotropic alignment of collagen fibres in musculoskeletal tissues is responsible for the resistance to mechanical loading, whilst in cornea is responsible for transparency. Herein, we evaluated the response of tenocytes, ...
Simulation of the Mechanical Response of Cells on Micropost Substrates
(American Society of Mechanical Engineers, 2013-09-20)
Experimental studies where cells are seeded on micropost arrays in order to quantify their contractile behavior are becoming increasingly common. Interpretation of the data generated by this experimental technique is ...
Regional modelling of the 21st century climate changes in the Irish Sea
(Elsevier, 2012-06)
An assessment of the complex evolution of climate change signals in the Irish Sea over the 21st century is presented in this paper. Potential impacts of climate change on the local hydrography are explored and interrelationships ...
Tide-surge interactions and their effects on total sea levels in Irish coastal waters
(Springer, 2013-06)
The research presented in this paper involves the application of the joint probability method to the estimation of extreme water levels resulting from astronomical tides and surge residuals and the investigation of the ...
Harvesting effects on biomass and nutrient retention in phragmites australis in a free-water surface constructed wetland in western Ireland
(The Royal Irish Academy, 2008-06-26)
The aim of this study was to examine the seasonal variation in biomass, total nitrogen (Tot-N) and total phosphorus (Tot-P) content of Phragmites australis in a 3-cell free-water surface (FWS) constructed wetland in western ...
DNA Immobilization and Detection on Cellulose Paper using a Surface Grown Cationic Polymer via ATRP
(American Chemical Society, 2012-02-02)
Cationic polymers with various structures have been widely investigated in the areas of medical diagnostics and molecular, biology because of their unique binding properties and capability to interact with biological ...