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Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar

Donnelly, Eleanor M.; Strappe, Padraig M.; McGinley, Lisa M.; Madigan, Nicolas N.; Geurts, Elizabeth; Rooney, Gemma E.; Windebank, Anthony J.; Fraher, John; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S. (Wiley, 2010)

Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ...

Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury

McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)

Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ...

Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes

Abu-Rub, Mohammad T.; Newland, Ben; Naughton, Michelle; Wang, Wenxin; McMahon, Siobhan; Pandit, Abhay (Elsevier, 2016-10-13)

Reactive astrocytosis and the subsequent glial scar is ubiquitous to injuries of the central nervous system, especially spinal cord injury (SCI) and primarily serves to protect against further damage, but is also a prominent ...

Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury

McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)

Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ...