Browsing Anatomy (Scholarly Articles) by Subject "glial scar"
Now showing items 1-3 of 3
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Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury
(Wiley, 2009-08-20)Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ... -
Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord
(Elsevier, 2012-01-08)Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ... -
Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar
(Wiley, 2010)Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ...