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Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury

Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan (Elsevier, 2018-09-26)

Background: The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an altemative model extremely attractive. The use ofex vivo slice cultures is an ...

Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar

Donnelly, Eleanor M.; Strappe, Padraig M.; McGinley, Lisa M.; Madigan, Nicolas N.; Geurts, Elizabeth; Rooney, Gemma E.; Windebank, Anthony J.; Fraher, John; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S. (Wiley, 2010)

Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ...

Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury

McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)

Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ...

Comparison of cellular architecture, axonal growth, and blood vessel formation through cell-loaded polymer scaffolds in the transected rat spinal cord

Madigan, Nicolas N.; Chen, Bingkun K.; Knight, Andrew M.; Rooney, Gemma E.; Sweeney, Eva; Kinnavane, Lisa; Yaszemski, Michael J.; Dockery, Peter; O'Brien, Timothy; McMahon, Siobhan S.; Windebank, Anthony J. (Mary Ann Liebert, 2014-08-08)

The use of multichannel polymer scaffolds in a complete spinal cord transection injury serves as a deconstructed model that allows for control of individual variables and direct observation of their effects on regeneration. ...

Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury

McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)

Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ...

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord

Donnelly, Eleanor M.; Madigan, Nicolas N.; Rooney, Gemma E.; Knight, Andrew; Chen, Bingkun; Ball, Bret; Kinnavane, Lisa; Garcia, Yolanda; Dockery, Peter; Fraher, John; Strappe, Padraig M.; Windebank, Anthony J.; O'Brien, Timothy; McMahon, Siobhan S. (Elsevier, 2012-01-08)

Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ...

Cell viability in three ex vivo rat models of spinal cord injury

Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan S. (Wiley, 2018-11-11)

Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ...