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dc.contributor.authorWilliamson, Paula R
dc.contributor.authorAltman, Douglas G
dc.contributor.authorBlazeby, Jane M
dc.contributor.authorClarke, Mike
dc.contributor.authorDevane, Declan
dc.contributor.authorGargon, Elizabeth
dc.contributor.authorTugwell, Peter
dc.date.accessioned2018-09-20T16:28:31Z
dc.date.available2018-09-20T16:28:31Z
dc.date.issued2012-08-06
dc.identifier.citationWilliamson, Paula R; Altman, Douglas G; Blazeby, Jane M; Clarke, Mike; Devane, Declan; Gargon, Elizabeth; Tugwell, Peter (2012). Developing core outcome sets for clinical trials: issues to consider. Trials 13 ,
dc.identifier.issn1745-6215
dc.identifier.urihttp://hdl.handle.net/10379/14439
dc.description.abstractThe selection of appropriate outcomes or domains is crucial when designing clinical trials in order to compare directly the effects of different interventions in ways that minimize bias. If the findings are to influence policy and practice then the chosen outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. There is a growing recognition that insufficient attention has been paid to the outcomes measured in clinical trials. These issues could be addressed through the development and use of an agreed standardized collection of outcomes, known as a core outcome set, which should be measured and reported, as a minimum, in all trials for a specific clinical area. Accumulating work in this area has identified the need for general guidance on the development of core outcome sets. Key issues to consider in the development of a core outcome set include its scope, the stakeholder groups to involve, choice of consensus method and the achievement of a consensus.
dc.publisherSpringer Nature
dc.relation.ispartofTrials
dc.subjectcore outcome set
dc.subjectoutcome reporting bias
dc.subjectclinical trials
dc.subjectsystematic review
dc.subjectmethodology
dc.subjectconsensus
dc.subjectbreast reconstruction
dc.subjectrheumatoid-arthritis
dc.subjectpatient perspective
dc.subjectsystematic reviews
dc.subjectcochrane reviews
dc.subjectfindings tables
dc.subjectdomains
dc.subjectdelphi
dc.subjectasthma
dc.subjectfibromyalgia
dc.titleDeveloping core outcome sets for clinical trials: issues to consider
dc.typeArticle
dc.identifier.doi10.1186/1745-6215-13-132
dc.local.publishedsourcehttps://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-13-132?site=trialsjournal.biomedcentral.com
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