dc.contributor.author | Tussiwand, Roxane | |
dc.contributor.author | Bosco, Nabil | |
dc.contributor.author | Ceredig, Rhodri | |
dc.contributor.author | Rolink, Antonius G. | |
dc.date.accessioned | 2018-09-20T16:27:14Z | |
dc.date.available | 2018-09-20T16:27:14Z | |
dc.date.issued | 2009-08-27 | |
dc.identifier.citation | Tussiwand, Roxane; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (2009). Tolerance checkpoints in b-cell development: johnny b good. European Journal of Immunology 39 (9), 2317-2324 | |
dc.identifier.issn | 0014-2980 | |
dc.identifier.uri | http://hdl.handle.net/10379/14229 | |
dc.description.abstract | B-cell development up to the immature B-cell stage takes place in the bone marrow, while final maturation into mature B cells occurs in the spleen. During differentiation, the precursor and immature B cells have to pass several checkpoints, including those in which they are censored for being auto-reactive, and therefore being potentially dangerous. Numerous studies have shown that the immature B-cell stage in the bone marrow and the transitional B-cell stages in the spleen comprise distinct checkpoints at which auto-reactivity is censored. Recently, evidence has been provided that the large pre-BII stage in the bone marrow, at which the pre-BCR is expressed, is yet another B-cell tolerance checkpoint. Here, we review these findings and speculate on directions for possible further experimentation. | |
dc.publisher | Wiley-Blackwell | |
dc.relation.ispartof | European Journal of Immunology | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | b cells | |
dc.subject | negative selection | |
dc.subject | positive selection | |
dc.subject | receptor editing | |
dc.subject | tolerance | |
dc.subject | surrogate-light-chain | |
dc.subject | heat-stable antigen(hi) | |
dc.subject | pre-b | |
dc.subject | bone-marrow | |
dc.subject | lymphocyte development | |
dc.subject | positive selection | |
dc.subject | allelic inclusion | |
dc.subject | autoimmune-disease | |
dc.subject | escape tolerance | |
dc.subject | deficient mice | |
dc.title | Tolerance checkpoints in b-cell development: johnny b good | |
dc.type | Article | |
dc.identifier.doi | 10.1002/eji.200939633 | |
dc.local.publishedsource | http://onlinelibrary.wiley.com/doi/10.1002/eji.200939633/pdf | |
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