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dc.contributor.authorTsoi, Lam C
dc.contributor.authorSpain, Sarah L
dc.contributor.authorKnight, Jo
dc.contributor.authorEllinghaus, Eva
dc.contributor.authorStuart, Philip E
dc.contributor.authorCapon, Francesca
dc.contributor.authorDing, Jun
dc.contributor.authorLi, Yanming
dc.contributor.authorTejasvi, Trilokraj
dc.contributor.authorGudjonsson, Johann E
dc.contributor.authorKang, Hyun M
dc.contributor.authorAllen, Michael H
dc.contributor.authorMcManus, Ross
dc.contributor.authorNovelli, Giuseppe
dc.contributor.authorSamuelsson, Lena
dc.contributor.authorSchalkwijk, Joost
dc.contributor.authorStåhle, Mona
dc.contributor.authorBurden, A David
dc.contributor.authorSmith, Catherine H
dc.contributor.authorCork, Michael J
dc.contributor.authorEstivill, Xavier
dc.contributor.authorBowcock, Anne M
dc.contributor.authorKrueger, Gerald G
dc.contributor.authorWeger, Wolfgang
dc.contributor.authorWorthington, Jane
dc.contributor.authorTazi-Ahnini, Rachid
dc.contributor.authorNestle, Frank O
dc.contributor.authorHayday, Adrian
dc.contributor.authorHoffmann, Per
dc.contributor.authorWinkelmann, Juliane
dc.contributor.authorWijmenga, Cisca
dc.contributor.authorLangford, Cordelia
dc.contributor.authorEdkins, Sarah
dc.contributor.authorAndrews, Robert
dc.contributor.authorBlackburn, Hannah
dc.contributor.authorStrange, Amy
dc.contributor.authorBand, Gavin
dc.contributor.authorPearson, Richard D
dc.contributor.authorVukcevic, Damjan
dc.contributor.authorSpencer, Chris C A
dc.contributor.authorDeloukas, Panos
dc.contributor.authorMrowietz, Ulrich
dc.contributor.authorSchreiber, Stefan
dc.contributor.authorWeidinger, Stephan
dc.contributor.authorKoks, Sulev
dc.contributor.authorKingo, Külli
dc.contributor.authorEsko, Tonu
dc.contributor.authorMetspalu, Andres
dc.contributor.authorLim, Henry W
dc.contributor.authorVoorhees, John J
dc.contributor.authorWeichenthal, Michael
dc.contributor.authorWichmann, H Erich
dc.contributor.authorChandran, Vinod
dc.contributor.authorRosen, Cheryl F
dc.contributor.authorRahman, Proton
dc.contributor.authorGladman, Dafna D
dc.contributor.authorGriffiths, Christopher E M
dc.contributor.authorReis, Andre
dc.contributor.authorKere, Juha
dc.contributor.authorDuffin, Kristina Callis
dc.contributor.authorHelms, Cindy
dc.contributor.authorGoldgar, David
dc.contributor.authorLi, Yun
dc.contributor.authorPaschall, Justin
dc.contributor.authorMalloy, Mary J
dc.contributor.authorPullinger, Clive R
dc.contributor.authorKane, John P
dc.contributor.authorGardner, Jennifer
dc.contributor.authorPerlmutter, Amy
dc.contributor.authorMiner, Andrew
dc.contributor.authorFeng, Bing Jian
dc.contributor.authorHiremagalore, Ravi
dc.contributor.authorIke, Robert W
dc.contributor.authorChristophers, Enno
dc.contributor.authorHenseler, Tilo
dc.contributor.authorRuether, Andreas
dc.contributor.authorSchrodi, Steven J
dc.contributor.authorPrahalad, Sampath
dc.contributor.authorGuthery, Stephen L
dc.contributor.authorFischer, Judith
dc.contributor.authorLiao, Wilson
dc.contributor.authorKwok, Pui
dc.contributor.authorMenter, Alan
dc.contributor.authorLathrop, G Mark
dc.contributor.authorWise, C
dc.contributor.authorBegovich, Ann B
dc.contributor.authorOnoufriadis, Alexandros
dc.contributor.authorWeale, Michael E
dc.contributor.authorHofer, Angelika
dc.contributor.authorSalmhofer, Wolfgang
dc.contributor.authorWolf, Peter
dc.contributor.authorKainu, Kati
dc.contributor.authorSaarialho-Kere, Ulpu
dc.contributor.authorSuomela, Sari
dc.contributor.authorBadorf, Petra
dc.contributor.authorHüffmeier, Ulrike
dc.contributor.authorKurrat, Werner
dc.contributor.authorKüster, Wolfgang
dc.contributor.authorLascorz, Jesús
dc.contributor.authorMössner, Rotraut
dc.contributor.authorSchürmeier-Horst, Funda
dc.contributor.authorStänder, Markward
dc.contributor.authorTraupe, Heiko
dc.contributor.authorBergboer, Judith G M
dc.contributor.authorHeijer, Martin den
dc.contributor.authorvan de Kerkhof, Peter C
dc.contributor.authorZeeuwen, Patrick L J M
dc.contributor.authorBarnes, Louise
dc.contributor.authorCampbell, Linda E
dc.contributor.authorCusack, Caitriona
dc.contributor.authorColeman, Ciara
dc.contributor.authorConroy, Judith
dc.contributor.authorEnnis, Sean
dc.contributor.authorFitzgerald, Oliver
dc.contributor.authorGallagher, Phil
dc.contributor.authorIrvine, Alan D
dc.contributor.authorKirby, Brian
dc.contributor.authorMarkham, Trevor
dc.contributor.authorMcLean, W H Irwin
dc.contributor.authorMcPartlin, Joe
dc.contributor.authorRogers, Sarah F
dc.contributor.authorRyan, Anthony W
dc.contributor.authorZawirska, Agnieszka
dc.contributor.authorGiardina, Emiliano
dc.contributor.authorLepre, Tiziana
dc.contributor.authorPerricone, Carlo
dc.contributor.authorMartín-Ezquerra, Gemma
dc.contributor.authorPujol, Ramon M
dc.contributor.authorRiveira-Munoz, Eva
dc.contributor.authorInerot, Annica
dc.contributor.authorNaluai, Åsa T
dc.contributor.authorMallbris, Lotus
dc.contributor.authorWolk, Katarina
dc.contributor.authorLeman, Joyce
dc.contributor.authorBarton, Anne
dc.contributor.authorWarren, Richard B
dc.contributor.authorYoung, Helen S
dc.contributor.authorRicano-Ponce, Isis
dc.contributor.authorTrynka, Gosia
dc.contributor.authorPellett, Fawnda J
dc.contributor.authorHenschel, Andrew
dc.contributor.authorAurand, Marin
dc.contributor.authorBebo, Bruce
dc.contributor.authorGieger, Christian
dc.contributor.authorIllig, Thomas
dc.contributor.authorMoebus, Susanne
dc.contributor.authorJöckel, Karl-Heinz
dc.contributor.authorErbel, Raimund
dc.contributor.authorDonnelly, Peter
dc.contributor.authorPeltonen, Leena
dc.contributor.authorBlackwell, Jenefer M
dc.contributor.authorBramon, Elvira
dc.contributor.authorBrown, Matthew A
dc.contributor.authorCasas, Juan P
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCraddock, Nicholas
dc.contributor.authorDuncanson, Audrey
dc.contributor.authorJankowski, Janusz
dc.contributor.authorMarkus, Hugh S
dc.contributor.authorMathew, Christopher G
dc.contributor.authorMcCarthy, Mark I
dc.contributor.authorPalmer, Colin N A
dc.contributor.authorPlomin, Robert
dc.contributor.authorRautanen, Anna
dc.contributor.authorSawcer, Stephen J
dc.contributor.authorSamani, Nilesh
dc.contributor.authorViswanathan, Ananth C
dc.contributor.authorWood, Nicholas W
dc.contributor.authorBellenguez, Céline
dc.contributor.authorFreeman, Colin
dc.contributor.authorHellenthal, Garrett
dc.contributor.authorGiannoulatou, Eleni
dc.contributor.authorPirinen, Matti
dc.contributor.authorSu, Zhan
dc.contributor.authorHunt, Sarah E
dc.contributor.authorGwilliam, Rhian
dc.contributor.authorBumpstead, Suzannah J
dc.contributor.authorDronov, Serge
dc.contributor.authorGillman, Matthew
dc.contributor.authorGray, Emma
dc.contributor.authorHammond, Naomi
dc.contributor.authorJayakumar, Alagurevathi
dc.contributor.authorMcCann, Owen T
dc.contributor.authorLiddle, Jennifer
dc.contributor.authorPerez, Marc L
dc.contributor.authorPotter, Simon C
dc.contributor.authorRavindrarajah, Radhi
dc.contributor.authorRicketts, Michelle
dc.contributor.authorWaller, Matthew
dc.contributor.authorWeston, Paul
dc.contributor.authorWidaa, Sara
dc.contributor.authorWhittaker, Pamela
dc.contributor.authorNair, Rajan P
dc.contributor.authorFranke, Andre
dc.contributor.authorBarker, Jonathan N W N
dc.contributor.authorAbecasis, Goncalo R
dc.contributor.authorElder, James T
dc.contributor.authorTrembath, Richard C
dc.date.accessioned2018-09-20T16:27:06Z
dc.date.available2018-09-20T16:27:06Z
dc.date.issued2012-11-11
dc.identifier.citationTsoi, Lam C; Spain, Sarah L; Knight, Jo; Ellinghaus, Eva; Stuart, Philip E; Capon, Francesca; Ding, Jun; Li, Yanming; Tejasvi, Trilokraj; Gudjonsson, Johann E; Kang, Hyun M; Allen, Michael H; McManus, Ross; Novelli, Giuseppe; Samuelsson, Lena; Schalkwijk, Joost; Ståhle, Mona; Burden, A David; Smith, Catherine H; Cork, Michael J; Estivill, Xavier; Bowcock, Anne M; Krueger, Gerald G; Weger, Wolfgang; Worthington, Jane; Tazi-Ahnini, Rachid; Nestle, Frank O; Hayday, Adrian; Hoffmann, Per; Winkelmann, Juliane; Wijmenga, Cisca; Langford, Cordelia; Edkins, Sarah; Andrews, Robert; Blackburn, Hannah; Strange, Amy; Band, Gavin; Pearson, Richard D; Vukcevic, Damjan; Spencer, Chris C A; Deloukas, Panos; Mrowietz, Ulrich; Schreiber, Stefan; Weidinger, Stephan; Koks, Sulev; Kingo, Külli; Esko, Tonu; Metspalu, Andres; Lim, Henry W; Voorhees, John J; Weichenthal, Michael; Wichmann, H Erich; Chandran, Vinod; Rosen, Cheryl F; Rahman, Proton; Gladman, Dafna D; Griffiths, Christopher E M; Reis, Andre; Kere, Juha; Duffin, Kristina Callis; Helms, Cindy; Goldgar, David; Li, Yun; Paschall, Justin; Malloy, Mary J; Pullinger, Clive R; Kane, John P; Gardner, Jennifer; Perlmutter, Amy; Miner, Andrew; Feng, Bing Jian; Hiremagalore, Ravi; Ike, Robert W; Christophers, Enno; Henseler, Tilo; Ruether, Andreas; Schrodi, Steven J; Prahalad, Sampath; Guthery, Stephen L; Fischer, Judith; Liao, Wilson; Kwok, Pui; Menter, Alan; Lathrop, G Mark; Wise, C; Begovich, Ann B; Onoufriadis, Alexandros; Weale, Michael E; Hofer, Angelika; Salmhofer, Wolfgang; Wolf, Peter; Kainu, Kati; Saarialho-Kere, Ulpu; Suomela, Sari; Badorf, Petra; Hüffmeier, Ulrike; Kurrat, Werner; Küster, Wolfgang; Lascorz, Jesús; Mössner, Rotraut; Schürmeier-Horst, Funda; Ständer, Markward; Traupe, Heiko; Bergboer, Judith G M; Heijer, Martin den; van de Kerkhof, Peter C; Zeeuwen, Patrick L J M; Barnes, Louise; Campbell, Linda E; Cusack, Caitriona; Coleman, Ciara; Conroy, Judith; Ennis, Sean; Fitzgerald, Oliver; Gallagher, Phil; Irvine, Alan D; Kirby, Brian; Markham, Trevor; McLean, W H Irwin; McPartlin, Joe; Rogers, Sarah F; Ryan, Anthony W; Zawirska, Agnieszka; Giardina, Emiliano; Lepre, Tiziana; Perricone, Carlo; Martín-Ezquerra, Gemma; Pujol, Ramon M; Riveira-Munoz, Eva; Inerot, Annica; Naluai, Åsa T; Mallbris, Lotus; Wolk, Katarina; Leman, Joyce; Barton, Anne; Warren, Richard B; Young, Helen S; Ricano-Ponce, Isis; Trynka, Gosia; Pellett, Fawnda J; Henschel, Andrew; Aurand, Marin; Bebo, Bruce; Gieger, Christian; Illig, Thomas; Moebus, Susanne; Jöckel, Karl-Heinz; Erbel, Raimund; Donnelly, Peter; Peltonen, Leena; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Craddock, Nicholas; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; McCarthy, Mark I; Palmer, Colin N A; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J; Samani, Nilesh; Viswanathan, Ananth C; Wood, Nicholas W; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Su, Zhan; Hunt, Sarah E; Gwilliam, Rhian; Bumpstead, Suzannah J; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T; Liddle, Jennifer; Perez, Marc L; Potter, Simon C; Ravindrarajah, Radhi; Ricketts, Michelle; Waller, Matthew; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Nair, Rajan P; Franke, Andre; Barker, Jonathan N W N; Abecasis, Goncalo R; Elder, James T; Trembath, Richard C (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics 44 (12), 1341-1348
dc.identifier.issn1061-4036,1546-1718
dc.identifier.urihttp://hdl.handle.net/10379/14210
dc.description.abstractTo gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TA GAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-kappa B signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.
dc.publisherSpringer Nature
dc.relation.ispartofNature Genetics
dc.subjectgenome-wide association
dc.subjectt-cell development
dc.subjectgene-expression
dc.subjectceliac-disease
dc.subjectth17 differentiation
dc.subjectsignaling pathways
dc.subjectnegative regulator
dc.subjectinterferon-gamma
dc.subjectcommon variants
dc.subjectmultiple common
dc.titleIdentification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
dc.typeArticle
dc.identifier.doi10.1038/ng.2467
dc.local.publishedsourcehttp://europepmc.org/articles/pmc3510312?pdf=render
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