Show simple item record

dc.contributor.authorSakellariou, Giorgos K.
dc.contributor.authorLightfoot, Adam P.
dc.contributor.authorEarl, Kate E.
dc.contributor.authorStofanko, Martin
dc.contributor.authorMcDonagh, Brian
dc.identifier.citationSakellariou, Giorgos K. Lightfoot, Adam P.; Earl, Kate E.; Stofanko, Martin; McDonagh, Brian (2017). Redox homeostasis and age-related deficits in neuromuscular integrity and function. Journal of Cachexia, Sarcopenia and Muscle 8 (6), 881-906
dc.description.abstractSkeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age-related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase. Despite the importance of this 'epidemic' problem, the primary biochemical and molecular mechanisms underlying age-related deficits in neuromuscular integrity and function have not been fully determined. Skeletal muscle generates reactive oxygen and nitrogen species (RONS) from a variety of subcellular sources, and age-associated oxidative damage has been suggested to be a major factor contributing to the initiation and progression of muscle atrophy inherent with ageing. RONS can modulate a variety of intracellular signal transduction processes, and disruption of these events over time due to altered redox control has been proposed as an underlying mechanism of ageing. The role of oxidants in ageing has been extensively examined in different model organisms that have undergone genetic manipulations with inconsistent findings. Transgenic and knockout rodent studies have provided insight into the function of RONS regulatory systems in neuromuscular ageing. This review summarizes almost 30 years of research in the field of redox homeostasis and muscle ageing, providing a detailed discussion of the experimental approaches that have been undertaken in murine models to examine the role of redox regulation in age-related muscle atrophy and weakness.
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscle
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Ireland
dc.subjectsuperoxide dismutase
dc.subjectneuromuscular junction
dc.subjectredox signalling
dc.subjectmotor neurons
dc.subjectskeletal-muscle fibers
dc.subjectnitric-oxide synthase
dc.subjectmanganese superoxide-dismutase
dc.subjectmethionine sulfoxide reductase
dc.subjectantioxidant enzyme-systems
dc.subjectelevated oxidative stress
dc.subjectearly embryonic lethality
dc.subjectdependent anion channels
dc.subjectreactive oxygen
dc.titleRedox homeostasis and age-related deficits in neuromuscular integrity and function

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Ireland
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Ireland