dc.contributor.author | Raymakers, A. J. N. | |
dc.contributor.author | Gillespie, P. | |
dc.contributor.author | O’Hara, M. C. | |
dc.contributor.author | Griffin, M. D. | |
dc.contributor.author | Dinneen, S. F. | |
dc.date.accessioned | 2018-09-20T16:22:31Z | |
dc.date.available | 2018-09-20T16:22:31Z | |
dc.date.issued | 2018-02-02 | |
dc.identifier.citation | Raymakers, A. J. N. Gillespie, P.; O’Hara, M. C.; Griffin, M. D.; Dinneen, S. F. (2018). Factors influencing health-related quality of life in patients with type 1 diabetes. Health and Quality of Life Outcomes 16 , | |
dc.identifier.issn | 1477-7525 | |
dc.identifier.uri | http://hdl.handle.net/10379/13605 | |
dc.description.abstract | Aims: Generic, preference-based measures of health-related quality of life (HRQoL) are a common input to the economic evaluation of new health technologies. As such, it is important to explore what characteristics of patients with Type 1 diabetes might impact scores on such measures.
Methods: This study utilizes baseline data from a cluster-randomized trial that recruited patients with Type 1 diabetes at six centers across Ireland. Health-related quality of life was assessed using the three-level EuroQol EQ-5D (EQ-5D) measure. Patients' responses to individual dimensions of the EQ-5D were explored. To see which patient factors influenced EQ-5D scores, multivariate regression analysis was conducted with EQ-5D scores as the outcome variable.
Results: Data was available for 437 Type 1 diabetes patients. The median age of these patients was 40 (IQR: 31-49) years and 53.8% were female. Overall, patients reported a high HRQoL based on EQ-5D scores (0.87 (SD: 0.19). Fifty-four percent of patients reported a perfect HRQoL. For those that reported problems, the most common dimension was the anxiety/depression dimension of the EQ-5D (29.6%). In the multivariate regression analysis, self-reported mental illness (-0.22 (95% CI: -0.34, -0.10)) and being unemployed (-0.07 (95% CI: -0.13, -0.02)) were negatively associated with EQ-5D scores (p < 0.05). The influence of self-reported mental illness was persistent in sensitivity analyses.
Conclusions: The study results indicate that patients with Type 1 diabetes report a high HRQoL based on responses to the EQ-5D. However, there are a substantial number of Type 1 diabetes patients that report problems in the anxiety/depression dimension, which may provide avenues to improve patients' HRQoL. | |
dc.publisher | Springer Nature | |
dc.relation.ispartof | Health and Quality of Life Outcomes | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | structured education | |
dc.subject | glycemic control | |
dc.subject | mellitus | |
dc.title | Factors influencing health-related quality of life in patients with type 1 diabetes | |
dc.type | Article | |
dc.identifier.doi | 10.1186/s12955-018-0848-4 | |
dc.local.publishedsource | https://hqlo.biomedcentral.com/track/pdf/10.1186/s12955-018-0848-4?site=hqlo.biomedcentral.com | |
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