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dc.contributor.authorMcVeigh, Terri Patricia
dc.contributor.authorMulligan, Robert J
dc.contributor.authorMcVeigh, Una Mary
dc.contributor.authorOwens, Patrick W
dc.contributor.authorMiller, Nicola
dc.contributor.authorBell, Marcia
dc.contributor.authorSebag, Frederic
dc.contributor.authorGuerin, Carole
dc.contributor.authorQuill, Denis
dc.contributor.authorWeidhaas, Joanne Barnes
dc.contributor.authorKerin, Michael
dc.contributor.authorLowery, Aoife J
dc.date.accessioned2018-09-20T16:17:32Z
dc.date.available2018-09-20T16:17:32Z
dc.date.issued2017-09-12
dc.identifier.citationMcVeigh, Terri Patricia; Mulligan, Robert J; McVeigh, Una Mary; Owens, Patrick W; Miller, Nicola; Bell, Marcia; Sebag, Frederic; Guerin, Carole; Quill, Denis; Weidhaas, Joanne Barnes; Kerin, Michael; Lowery, Aoife J (2017). Investigating the association of rs2910164 with cancer in irish patients. Endocrine Connections 6 (8), 614-624
dc.identifier.issn2049-3614,2049-3614
dc.identifier.urihttp://hdl.handle.net/10379/12855
dc.description.abstractIntroduction: MicroRNAs (miRNAs) are small noncoding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger RNA (mRNA). Polymorphisms in genes encoding miRNAs or in miRNA-mRNA binding sites confer deleterious epigenetic effects on cancer risk. miR-146a has a role in inflammation and may have a role as a tumour suppressor. The polymorphism rs2910164 in the MIR146A gene encoding pre-miR-146a has been implicated in several inflammatory pathologies, including cancers of the breast and thyroid, although evidence for the associations has been conflicting in different populations. We aimed to further investigate the association of this variant with these two cancers in an Irish cohort. Methods: The study group comprised patients with breast cancer (BC), patients with differentiated thyroid cancer (DTC) and unaffected controls. Germline DNA was extracted from blood or from saliva collected using the DNA Genotek Oragene 575 collection kit, using crystallisation precipitation, and genotyped using TaqMan-based PCR. Data were analysed using SPSS, v22. Results: The total study group included 1516 participants. This comprised 1386 Irish participants; 724 unaffected individuals (controls), 523 patients with breast cancer (BC), 136 patients with differentiated thyroid cancer (DTC) and three patients with dual primary breast and thyroid cancer. An additional cohort of 130 patients with DTC from the South of France was also genotyped for the variant. The variant was detected with a minor allele frequency (MAF) of 0.19 in controls, 0.22 in BC and 0.27 and 0.26 in DTC cases from Ireland and France, respectively. The variant was not significantly associated with BC (per allele odds ratio = 1.20 (0.98-1.46), P = 0.07), but was associated with DTC in Irish patients (per allele OR = 1.59 (1.18-2.14), P = 0.002). Conclusion: The rs2910164 variant in MIR146A is significantly associated with DTC, but is not significantly associated with BC in this cohort.
dc.publisherBioScientifica
dc.relation.ispartofEndocrine Connections
dc.subjectthyroid
dc.subjectendocrine cancers
dc.subjectpapillary thyroid-cancer
dc.subjectmultiple primary breast
dc.subjectmicrorna polymorphisms
dc.subjectiranian population
dc.subjectchinese population
dc.subjectnoncoding rna
dc.subjectmir-146a
dc.subjectrisk
dc.subjectsusceptibility
dc.subjectcarcinoma
dc.titleInvestigating the association of rs2910164 with cancer in irish patients
dc.typeArticle
dc.identifier.doi10.1530/ec-17-0196
dc.local.publishedsourcehttp://www.endocrineconnections.com/content/6/8/614.full.pdf
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