High nuclearity carbonyl clusters as near-ir contrast agents for photoacoustic in vivo imaging
View/ Open
Full Text
Date
2016-01-01Author
Lam, Zhiyong
Balasundaram, Ghayathri
Kong, Kien Voon
Chor, Bo Yang
Goh, Douglas
Khezri, Bahareh
Webster, Richard D.
Leong, Weng Kee
Olivo, Malini
Metadata
Show full item recordUsage
This item's downloads: 0 (view details)
Cited 4 times in Scopus (view citations)
Recommended Citation
Lam, Zhiyong; Balasundaram, Ghayathri; Kong, Kien Voon; Chor, Bo Yang; Goh, Douglas; Khezri, Bahareh; Webster, Richard D. Leong, Weng Kee; Olivo, Malini (2016). High nuclearity carbonyl clusters as near-ir contrast agents for photoacoustic in vivo imaging. J. Mater. Chem. B 4 (22), 3886-3891
Published Version
Abstract
High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na-2[Os-10(mu(6)-C)(CO)(24)] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.