High nuclearity carbonyl clusters as near-ir contrast agents for photoacoustic in vivo imaging
Kong, Kien Voon
Chor, Bo Yang
Webster, Richard D.
Leong, Weng Kee
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Lam, Zhiyong; Balasundaram, Ghayathri; Kong, Kien Voon; Chor, Bo Yang; Goh, Douglas; Khezri, Bahareh; Webster, Richard D. Leong, Weng Kee; Olivo, Malini (2016). High nuclearity carbonyl clusters as near-ir contrast agents for photoacoustic in vivo imaging. J. Mater. Chem. B 4 (22), 3886-3891
High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na-2[Os-10(mu(6)-C)(CO)(24)] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.