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dc.contributor.authorGorman, Adrienne M.
dc.date.accessioned2018-09-20T16:09:28Z
dc.date.available2018-09-20T16:09:28Z
dc.date.issued2008-07-10
dc.identifier.citationGorman, Adrienne M. (2008). Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. Journal of Cellular and Molecular Medicine 12 (6), 2263-2280
dc.identifier.issn1582-1838
dc.identifier.urihttp://hdl.handle.net/10379/11694
dc.description.abstractNeuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro-survival strategies are discussed.
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.subjectalzheimer's disease (ad)
dc.subjectapoptosis
dc.subjectautophagic cell death (acd)
dc.subjectautophagy
dc.subjectendoplasmic reticulum (er) stress
dc.subjectexcitotoxicity
dc.subjectheat shock proteins (hsps)
dc.subjecthuntington's disease (hd)
dc.subjectischaemia
dc.subjectparkinson's disease (pd)
dc.subjectprotein aggregation
dc.subjectubiquitin-proteasome system (ups)
dc.subjectunfolded protein response (upr)
dc.subjectendoplasmic-reticulum stress
dc.subjectubiquitin-proteasome system
dc.subjectfocal cerebral-ischemia
dc.subjectcytochrome-c release
dc.subjectamyloid precursor protein
dc.subjectmutant alpha-synuclein
dc.subjectparkinsons-disease
dc.subjectalzheimers-disease
dc.subjecthuntingtons-disease
dc.subjectmitochondrial dysfunction
dc.titleNeuronal cell death in neurodegenerative diseases: recurring themes around protein handling
dc.typeArticle
dc.identifier.doi10.1111/j.1582-4934.2008.00402.x
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2008.00402.x/pdf
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