dc.contributor.author | de Oliveira, Fernando C. S. | |
dc.contributor.author | Olvera, Dinorath | |
dc.contributor.author | Sawkins, Michael J. | |
dc.contributor.author | Cryan, Sally-Ann | |
dc.contributor.author | Kimmins, Scott D. | |
dc.contributor.author | da Silva, Tatiane Eufrasio | |
dc.contributor.author | Kelly, Daniel J. | |
dc.contributor.author | Duffy, Garry P. | |
dc.contributor.author | Kearney, Cathal | |
dc.contributor.author | Heise, Andreas | |
dc.date.accessioned | 2018-09-20T16:05:27Z | |
dc.date.available | 2018-09-20T16:05:27Z | |
dc.date.issued | 2017-11-14 | |
dc.identifier.citation | de Oliveira, Fernando C. S. Olvera, Dinorath; Sawkins, Michael J.; Cryan, Sally-Ann; Kimmins, Scott D.; da Silva, Tatiane Eufrasio; Kelly, Daniel J.; Duffy, Garry P.; Kearney, Cathal; Heise, Andreas (2017). Direct uv-triggered thiol–ene cross-linking of electrospun polyester fibers from unsaturated poly(macrolactone)s and their drug loading by solvent swelling. Biomacromolecules 18 (12), 4292-4298 | |
dc.identifier.issn | 1525-7797,1526-4602 | |
dc.identifier.uri | http://hdl.handle.net/10379/11104 | |
dc.description.abstract | Electrospinning is considered a relatively simple and versatile technique to form high porosity porous scaffolds with micron to nanoscale fibers for biomedical applications. Here, electrospinning of unsaturated aliphatic polyglobalide (PG1) into well-defined fibers with an average diameter of 9 mu m is demonstrated. Addition of a dithiol cross-linker and a photoinitiator to the polymer solution enabled the UV-triggered intracross-linking of the fibers during the spinning process. The in situ cross-linking of the fibers resulted in amorphous material able to swell up to 14% in tetrahydrofurane (THF) without losing the fiber morphology. Seeding mesenchymal stem cells (MSCs) onto both cross-linked and non-cross-linked PG1 fibers proved their compatibility with MSCs and suitability as scaffolds for cell growth and proliferation of MSCs. Moreover, the ability to directly load cross-linked PG1 with hydrophobic molecules by soaking the fiber mesh in solution is shown with Rhodamine B and Indomethacin, a hydrophobic anti-inflammatory drug. This marks an advantage over conventional aliphatic polyesters and opens opportunities for the design of drug loaded polyester scaffolds for biomedical applications or tissue engineering. | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.ispartof | Biomacromolecules | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Ireland | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ie/ | |
dc.subject | ring-opening polymerization | |
dc.subject | poly-epsilon-caprolactone | |
dc.subject | high-molecular-weight | |
dc.subject | omega-pentadecalactone | |
dc.subject | nanofibrous scaffolds | |
dc.subject | mechanical-properties | |
dc.subject | regenerative medicine | |
dc.subject | macrolactones | |
dc.subject | delivery | |
dc.subject | copolymers | |
dc.title | Direct uv-triggered thiol–ene cross-linking of electrospun polyester fibers from unsaturated poly(macrolactone)s and their drug loading by solvent swelling | |
dc.type | Article | |
dc.identifier.doi | 10.1021/acs.biomac.7b01335 | |
dc.local.publishedsource | http://www.tara.tcd.ie/bitstream/2262/82485/1/Oliveira%20et%20al%20Biomacromolecues%202017.pdf | |
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