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dc.contributor.authorCowman, Jonathan
dc.contributor.authorDunne, Eimear
dc.contributor.authorOglesby, Irene
dc.contributor.authorByrne, Barry
dc.contributor.authorRalph, Adam
dc.contributor.authorVoisin, Bruno
dc.contributor.authorMüllers, Sieglinde
dc.contributor.authorRicco, Antonio J.
dc.contributor.authorKenny, Dermot
dc.date.accessioned2018-09-20T16:04:17Z
dc.date.available2018-09-20T16:04:17Z
dc.date.issued2015-07-16
dc.identifier.citationCowman, Jonathan; Dunne, Eimear; Oglesby, Irene; Byrne, Barry; Ralph, Adam; Voisin, Bruno; Müllers, Sieglinde; Ricco, Antonio J. Kenny, Dermot (2015). Age-related changes in platelet function are more profound in women than in men. Scientific Reports 5 ,
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10379/10939
dc.description.abstractAge is a risk factor for cardiovascular disease (CVD), however the effect of age on platelet function remains unclear. Ideally, platelet function should be assayed under flow and shear conditions that occur in vivo. Our study aimed to characterise the effect of age on platelet translocation behaviour using a novel flow-based assay that measures platelet function in less than 200 mu l of blood under conditions of arterial shear. Blood from males (n = 53) and females (n = 56), ranging in age from 19-82 and 21-70 respectively were perfused through custom-made parallel plate flow chambers coated with immobilised human von Willebrand Factor (VWF) under arterial shear (1,500s(-1)). Platelet translocation behaviour on VWF was recorded by digital-image microscopy and analysed. The study showed that aging resulted in a significant decrease in the number of platelet tracks, translocating platelets and unstable platelet interactions with VWF. These age related changes in platelet function were more profound in women than in men indicating that age and gender significantly impacts on platelet interactions with VWF.
dc.publisherSpringer Nature
dc.relation.ispartofScientific Reports
dc.subjectestrogen-receptor-beta
dc.subjectvon-willebrand-factor
dc.subjecthuman megakaryocytes
dc.subjectadvancing age
dc.subjectin-vitro
dc.subjectaggregation
dc.subjectadhesion
dc.subjectcontain
dc.subjectflow
dc.titleAge-related changes in platelet function are more profound in women than in men
dc.typeArticle
dc.identifier.doi10.1038/srep12235
dc.local.publishedsourcehttps://doi.org/10.1038/srep12235
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