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dc.contributor.authorBroderick, Ronan
dc.contributor.authorNasheuer, Heinz-Peter
dc.date.accessioned2018-09-20T16:01:41Z
dc.date.available2018-09-20T16:01:41Z
dc.date.issued2009-08-01
dc.identifier.citationBroderick, Ronan; Nasheuer, Heinz-Peter (2009). Regulation of cdc45 in the cell cycle and after dna damage. Biochemical Society Transactions 37 , 926-930
dc.identifier.issn0300-5127,1470-8752
dc.identifier.urihttp://hdl.handle.net/10379/10543
dc.description.abstractThe Cdc (cell division cycle) 45 protein has a central role in the regulation of the initiation and elongation stages of eukaryotic chromosomal DNA replication. In addition, it is the main target for a Chk1 (checkpoint kinase i)-dependent Cdc25/CDK2 (cyclin-dependent kinase 2)-independent DNA damage checkpoint signal transduction pathway following low doses of 8PDE (benzo[a]pyrene dihydrodiol epoxide) treatment, which causes DNA damage similar to UV-induced adducts. cdc45 interacts physically and functionally with the putative eukaryotic replicative DNA helicase, the MCM (mini-chromosome maintenance) complex, and forms a helicase active 'supercomplex', the CMG [cdc45-MCM2-7-GINS (go-ichi-ni-san)] complex. These known protein-protein interactions, as well as unknown interactions and post-translational modifications, may be important for the regulation of Cdc45 and the initiation of DNA replication following DNA damage. Future studies will help to elucidate the molecular basis of this newly identified S-phase checkpoint pathway which has Cdc45 as a target.
dc.publisherPortland Press Ltd.
dc.relation.ispartofBiochemical Society Transactions
dc.subjectcdc45
dc.subjectcell cycle
dc.subjectcheckpoint
dc.subjectDNA damage
dc.subjectDNA replication
dc.subjectgenome stability
dc.subjects-phase
dc.subjectminichromosome maintenance
dc.subjectpolymerase-alpha
dc.subjectchromosomal DNA
dc.subjectsaccharomyces-cerevisiae
dc.subjecthelicase activity
dc.subjectreplication fork
dc.subjectmcm2-7 complex
dc.subjectinitiation
dc.subjectsubunit
dc.titleRegulation of cdc45 in the cell cycle and after dna damage
dc.typeArticle
dc.identifier.doi10.1042/bst0370926
dc.local.publishedsourcehttp://www.biochemsoctrans.org/content/ppbiost/37/4/926.full.pdf
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